Showing posts with label sociology of science. Show all posts
Showing posts with label sociology of science. Show all posts

Sunday, February 1, 2026

Neuroscientists Keep Peddling Explanatory Snake Oil

 In the nineteenth century a widely practiced scam was the sale of snake oil. A snake oil salesman would typically travel around from town to town, typically new towns in the western United States that had a shortage of doctors.  He would often travel in a horse-pulled wagon called a medicine wagon. The snake oil salesman would make all kinds of groundless claims about the medicinal value of his worthless bottles. After a good day's sale, the snake oil salesman would be off to the next town. By keeping on the road, he would avoid the problem of customers demanding their money back because the product failed to work. Below we see a newspaper ad placed by one of the traveling snake oil salesmen:

snake oil ad

Notice the sweeping claim in the ad: the claim that the seller could "heal all manner of disease." Typically the person making such a claim would be selling products of little or no medicinal value. 

As the Wild, Wild West of the United States got more and more tame and adequately filled by regular doctors, snake oil treatments fell into disrepute, and the very term "snake oil" became a term synonymous with cons and cheats. But it is easy to imagine how snake oil manufacturers could have caused snake oil to become very prestigious.  All that would have been needed was the establishment of Departments of Snake Oil Medicine in colleges and universities, populated by Professors of Snake Oil Medicine. 

Once some type of claim gets taught by some type of department in colleges and universities, the public starts thinking of the claim as respectable and well-founded. What happens is that a university or college has great prestige, and is regarded as a lofty teacher of truth and a storehouse of knowledge. So when some new claim gets institutionalized by the establishment of a university department or college department, people tend to think such a claim is well-established. If there were hundreds of Departments of Astrology in colleges and universities all over the country, people would tend to think that astrology is well-established, and that consulting your horoscope is a good way to judge your future. 

We can imagine Departments of Snake Oil Medicine getting established in universities and colleges, aided by the social construction of the triumphal legend that snake oil advocates like Texas Jack were giants of medicine whose authority we should kneel to:

But how could some Department of Snake Oil Medicine ever produce research that would give some veneer or aura of scientific respectability to the claims of snake oil advocates? That would be relatively easy. A variety of bad research techniques could be employed. It would work rather like this:

(1) When snake oil advocates did studies that showed no medical effectiveness in people using snake oil, such studies would simply be filed away in the file drawers of scientists, and not submitted for publication. 

(2) Snake oil advocates would run very small studies, and by pure chance a certain number of them (maybe 5% or so) would seem to show marginal effectiveness. Such studies would be the ones submitted for publication in journals. 

(3) Noise-mining and cherry-picking could be heavily utilized. The case histories of thousands of snake oil users could be very carefully scanned, to look for cases in which some type of ailment (perhaps an infectious disease such as the flu) seemed to become less troubling at about the same time someone had drunk or applied snake oil. Such cases would be heavily promoted as proof of the wonderful effectiveness of snake oil. 

(4) Bad measurement techniques and poor analysis techniques could be used when evaluating someone's health, allowing a kind of see-what-you-are-hoping-to-see analysis. For example, when studying the effectiveness of snake oil in treating fevers, snake oil advocates might rely on dubious "rate how you feel on a scale of 1 to 10" survey answers, rather than much more reliable thermometer measures of a person's temperature. 

(5) Misleading visuals might be used, such as body maps showing in bright red regions of the body allegedly treatable by snake oil medicine. 

By the use of such techniques and many similar misleading and poor-practice techniques, Professors of Snake Oil Medicine could easily produce papers or articles that seemed to provide superficial evidence for the effectiveness of snake oil treatments, even though the treatments had no effectiveness. And if the Professors of Snake Oil Medicine were to get heavy funding (directly or indirectly) from snake oil manufacturers who made tons of money from selling snake oil, we can imagine that many university and college Departments of Snake Oil Medicine could stay well-funded. Of course, such professors would have a strong financial motive to produce results pleasing to their corporate sponsors. 

corporate-funded professor

 In a previous post I stated the rule below:

The rule of well-funded and highly motivated research communities: almost any large well-funded research community eagerly desiring to prove some particular claim can be expected to  occasionally produce superficially persuasive evidence in support of such a claim, even if the claim is untrue.  

Such a rule would help Professors of Snake Oil Medicine to be able to claim that they were producing some studies in support of their claims. What would also help very much would be if the Professors of Snake Oil Medicine were to succeed in enforcing taboos and if such professors were to succeed in demonizing, slandering and gaslighting all those who presented evidence against the effectiveness of snake oil.  If such professors somehow made it a taboo to do research discrediting the claims of snake oil proponents, that would be a huge element in helping Departments of Snake Oil Medicine to become well-established.

Now, you may think that the imaginary tale I describe above is one too hard to believe. But the truth is that there actually occurred something very much like what I have described above. What happened is that they established in colleges and universities Departments of Neuroscience dedicated to the propagation of the belief that minds are produced by brains, and that brains are the storage place of human memories. Such claims were very much explanatory snake oil. Although countless billions of dollars have been spent trying to prove such claims, they have never been established by robust evidence. To the contrary, research on brains has produced innumerable reasons for rejecting the claim that minds are produced by brains, and that brains are the storage place of human memories. Such reasons are discussed in the posts of this blog site. 

So how is it that our Departments of Neuroscience have stayed in business and had such high influence? How have Professors of Neuroscience got so many people to believe the unbelievable dogmas they teach? This occurred because such professors used techniques just like I described above. Some of the techniques that such professors have used are listed below:

  • Quick and dirty" experimental designs
  • Way-too-small study group sizes
  • Cherry-picked data subsets
  • Ignoring two hundred years of well-documented psychical research presenting evidence contrary to neuroscientist dogmas
  • Unreliable claims about fear or recall in rodents, produced by bad measurement methods such as "freezing behavior" estimations 
  • Citations of poor-quality papers
  • "Keep torturing the data until it confesses" tactics
  • Constant reiterations of dogmas disproven or discredited by the facts observed by neuroscientists themselves
  • Ignoring unusual case histories that conflict with "brains make minds" claims or "brains store memories" claims
  • "Lying with colors" fMRI studies containing misleading visuals
  • Lack of pre-registration
  • Weird programming loop contortions of data, in which investigators senselessly think they have the right to programmatically perform arbitrary convolutions on the original data and still claim their twisted output is "what the brain is telling us"
  • Professor pareidolia resembling "Jesus in my toast" claims
  • Ignoring physical shortfalls of all brains that contradict or discredit some hypothesis being tested
  • Unreliable and convoluted "spaghetti code" analysis
  • Lack of detailed blinding protocols
  • Ignoring observation failures
  • Poor reproducibility
  • HARKing 
  • Not publishing null results
  • P-hacking
  • Title or abstract claims not matching results
  • Lack of control subjects, or too few of them
  • Blending real data and artificial (fake) data, with the fake data called "simulated" as if something "simulated" was better than something fake
  • Unwarranted use of cell names and cell nicknames
  • Unwarranted assumptions of causal effects, with a massive failure to consider reasonable alternative explanations of causes
  • By a constant use of the passive voice rather than the active voice, a failure to document in most scientific papers the most basic facts needed to help police fraud, facts such as exactly who made an observation, the exact date when the observation was made, and where the observation was made. 

Today's professors of neuroscience do not get payments from snake oil manufacturers. But they often receive (directly or indirectly) very big financial benefits from pharmaceutical manufacturers and the manufacturers of biomedical devices, who may fund research or offer lucrative consulting fees for professors making claims that enhance the stock prices of such manufacturers.  

bribed neuroscientist


Just as I imagined Professors of Snake Oil Medicine creating some taboo against research challenging the effectiveness of snake oil, with such professors using techniques of gaslighting and slander to marginalize researchers producing such research, professors of neuroscience have used similar techniques to try to create some taboo against research challenging the "brains make minds" dogma. We have two hundred years of published research documenting the reality of spooky mental phenomena that cannot be explained by brains,  things such as ESP, clairvoyance, paranormal phenomena, apparition sightings, out-of-body experiences and near-death experiences. The professors of neuroscience have declared such research topics to be taboo, and have ignored all of the psychical research that defies their "brains make minds" dogma. Such professors have tried to gaslight, slander and marginalize respectable researchers producing such results that defy brains make minds" dogma.

The "smoke and mirrors" world of modern neuroscience resembles the "smoke and mirrors" shenanigans that would have gone on within Departments of Snake Oil Medicine if they had ever been established.  For a look at a recent example of some of this foolishness, read the recent "Mad in America" article here.  We read of a patient who would not give "informed consent" to a treatment risking her life, who was electrically shocked until she relented, with this being hailed as "restoring decision-making capacity," in some twisted mess of neurobabble. 

smoke and mirrors neuroscience

A recent article in The Atlantic is entitled "Science Is Drowning In AI Slop." We read that soon after the popular ChatGPT AI program was introduced a few years ago, there was a huge spike in submissions to science journals and science preprint servers. We can imagine how that worked:  scientists stuffing their papers with lots of AI-generated paragraphs and AI-generated charts. We read that some researchers who would rarely submit a paper to a journal are now submitting dozens per year. We read that scientists are running machine-learning algorithms on data, claiming to have produced some interesting outcome. The article calls this "a fraud template for AI researchers," noting "as long as the outcome isn't too interesting, few people, if any, will bother to vet it." 

I was for a long time a software developer, and I know how to read programming code. When I look at the programming code used for some of the low-quality "keep torturing the data until it confesses" neuroscience papers that I read, I will often see code that makes me think something along the lines of "no human would ever write junk this unreadable."  My guess is that neuroscientists are sometimes using AI-generated computer code to do black-box "analytics" on brain scan data and EEG data. I suspect that often both the code and the description of the code in the paper is AI-generated, and that often the author or authors do not even understand very well what the code is doing. The obscure output from such a thing is correctly described as AI slop. But a human peer reviewer may be unlikely to catch the nonsense, partially because (according to the article) much of peer review is now done by AI rather than humans. Another article about a popular scientific preprint server states, "Starting in early 2025, he says, the number of 'AI slop' submissions went up exponentially."

We read this, referring to the LLM algorithms used by AI programs:

"Other preprint servers have also seen a rise in poor, AI-generated content, Nosek says—including the generalist preprint service hosted by OSF, which stopped accepting any new submissions in August 2025 'because a majority of submissions were very low quality.'  PsyArXiv, a community-run psychology preprint server within OSF, swapped from moderating submissions after posting to moderating them in advance for the same reason.  Wijers says the new safeguard is needed in part because LLMs will improve, making it harder or impossible for moderators to distinguish fake AI-generated papers from legitimate work."

Wednesday, September 10, 2025

Neuroscientists Financially Entangled With Biotech Device Makers Produce Flawed Studies

On the week I am writing this post auto-scheduled for later publication, I am observing what so often goes on in news reporting about science: a host of science news sites mindlessly parroting the unjustified claims of a university press release.  You would think that by now our science journalists might have learned the lesson that university press releases these days are often notorious for their hype, errors and misinformation, and that the claims of such press releases should be subjected to critical scrutiny. 

The unfounded claim this week is one that at-home magnetic brain stimulation "shows promise" for treating depression. The claims come from a Kings College press release here, which is entitled "At home brain stimulation for depression found to be safe and effective." We have a discussion of a new study testing at-home head gadgets using something called transcranial direct current stimulation (tDCS),

The press release states this:

"Transcranial direct current stimulation (tDCS) is a form of self-administered, non-invasive brain stimulation that applies a weak, direct current of between 0.5 to 2 milliampere to the scalp via two electrodes. It is not electroconvulsive therapy (ECT), which delivers about 800 milliamperes to the brain causing a generalised seizure and can only be conducted under strict supervision. 

174 participants aged 18 and over, and with a diagnosis of at least moderate depression were randomly assigned to one of two treatment arms; 'active' tDCS or 'inactive' tDCS which was the same device but did not provide a current. Participants had a 10-week course of treatment, initially having five 30-minute sessions a week for the first three weeks, followed by three 30-minute sessions a week for the following seven weeks.

Researchers found that participants in the active arm of the trial showed significant improvements in the severity of their depression, as well as the overall clinical response and remission compared to those in the ‘inactive’ placebo control arm. The rates of treatment response and remission were three times higher in the active treatment arm compared to the placebo arm, where 44.9% in the active arm demonstrated a remission rate compared to 21.8% of the control group."

A study like this attempts to follow the conventions of randomized controlled trials (RCT) using placebos.  In such studies patients are randomly assigned to either a medication group or a placebo group. Typically the medication group gets some medicine being tested, and the placebo group gets only a similar-looking placebo pill that is something like a sugar pill that looks just like the real medicine. The patient does not know which group he belongs to, and does not know  whether the pill he is being given is just a placebo sugar pill. Such a lack of knowledge is called an example of blinding. Such a randomized control trial attempts to see some medical outcome in the group getting the real medication that is superior to the medical outcome reported in the placebo group. When both a doctor or scientist and the patient are unaware (for at least part of the time)  whether particular patients belong to the get-the-real-treatment group or the placebo control group, such a study is called a "double-blind" study. 

The press release quoted above refers to the study here, entitled "Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial." The study claims to have been a double-blind study, saying that it was a "fully remote, multisite, double-blind, placebo-controlled, randomized superiority trial."  But the claim about being double-blind is not correct. The patients who were supposed to be blind as to whether or not they were getting the real magnetic stimulation were  not really blind about such a thing. 

The failure of the blinding protocol to achieve real blindness (a lack of knowledge by subjects about whether they were receiving the real treatment) is shown by the section of the paper entitled "Analysis of study blinding and unblinding." There we read this:

"Before unblinding at week 10 (end of trial), participants were asked to guess whether they thought they were receiving the active or sham tDCS device and their level of certainty, rating from ‘1’ for ‘very uncertain’ to ‘5’ for to ‘very certain’. A guess of active tDCS was made by 77.6% in the active treatment arm and 59.3% in the sham treatment arm; the difference was significant (P = 0.01)."

This is a very big difference. 77% of the people getting the real treatment thought they were getting the real treatment, but only 59% of the people in the "no treatment" placebo group thought they were getting the real treatment.  This indicates a very major effect in which the people getting the real treatment were much more likely to think that they were getting the real treatment than those not getting the real treatment. In a randomized control trial that achieves an effective level of blinding, there will be no difference between the percentage of real-treatment subjects and placebo or sham treatment subjects who thought they were getting the real treatment. 

Analyzing the paper, it's easy to see why patients who were not getting the real treatment would have been been better able to figure out whether they were getting the real treatment. We read this:

"Active stimulation consisted of 2 mA direct current stimulation for 30 min with gradual ramp up over 120 s at the start and ramp down over 15 s at end of the session. Sham stimulation with the same device and app was used to resemble the active intervention and to receive the treatment schedule. An initial ramp up from 0 to 1 mA over 30 s then ramp down to 0 mA over 15 s was repeated at the end of the session to cause a tingling sensation that mimics active stimulation."

So the people getting the real treatment got 30 minutes of real direct current stimulation of their head, but the people getting the sham or placebo treatment got only about 30 seconds of real direct current stimulation. Such a big difference helps explains why a much higher percentage of those getting the real treatment thought they were getting the real treatment. 

That much higher percentage is enough to explain the difference in the reported relief of depression symptoms, even while assuming that the head device had zero real effectiveness in treating depression. Being much more likely to think that they had got some possibly effective  real brain zapping effect, the people in the real treatment group were much more likely to get a placebo effect that was largely the power of suggestion. Similarly, assign two groups of patients sugar-pill placebos, telling the first group that the pill is a powerful anti-depressant, and the second that the pill is just a vitamin, then the first group will probably report significant improvement in their depression, because of placebo effects and the power of suggestion. 

Nowadays biotech companies may have a very large incentive to fund and/or promote poorly designed and executed brain research, particularly whenever such research helps to promote some device that such companies sell. Biotech companies include very many companies such as the manufacturers of MRI devices, the manufacturers of EEG equipment, the manufacturers of implantable medical devices, and the manufacturers of noninvasive brain-related devices that a person may put on his head. The biotech industry is a trillion-dollar industry, and many billions of that involves brain-related products. 

Neuroscientists these days are thoroughly entangled with pharmaceutical companies and the manufacturers of biotech devices. The entanglement casts great doubt on the objectivity of any such scientists doing studies relating to the effectiveness of any brain-related medicine or any brain-related medical device. These entanglements and their pernicious effects on the objectivity of neuroscientists is discussed in my post "How the Academia-Cyberspace-Pharmaceutical-Biotech-Publishing Complex Incentivizes Bad Brain Research," which you can read here. 

The diagram below illustrates some of the entanglements and conflicts of interest going on:

who profits from bad research

Whenever you read a science paper that seems to promote some medicine or medical device, it is always a good idea to study the "Competing Interests" section of the paper, in which scientists are supposed to reveal possible conflicts of interest that may have affected their objectivity. When you examine that "Competing Interests" section of the paper being discussed, all kinds of alarm bells should go off. Here it is:

"C.H.Y.F. reports the following competing interests: research grant funding on behalf of the University of East London from Flow Neuroscience (no. R102696); research grant funding from NIMH (no. R01MH134236), the Baszucki Brain Research Fund Milken Institute (no. BD0000009), the Rosetrees Trust (no. CF20212104), the International Psychoanalytic Society (no. 158102845), the MRC (no. G0802594), NARSAD and the Wellcome Trust. She is Associate Editor of Psychoradiology and Section Editor of the Brain Research Bulletin. A.H.Y. reports the following competing interests: paid lectures and advisory boards for the following companies with therapies used in affective and related disorders: Flow Neuroscience, Novartis, Roche, Janssen, Takeda, Noema Pharma, Compass, AstraZeneca, Boehringer Ingelheim, Eli Lilly, LivaNova, Lundbeck, Sunovion, Servier, LivaNova, Janssen, Allegan, Bionomics, Sumitomo Dainippon Pharma, Sage, Novartis and Neurocentrx. He is principal investigator for the following studies: the Restore-Life VNS registry study funded by LivaNova; ESKETINTRD3004: ‘An Open-label, Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression’; The Effects of Psilocybin on Cognitive Function in Healthy Participants; The Safety and Efficacy of Psilocybin in Participants with Treatment-Resistant Depression (P-TRD); A Double-Blind, Randomized, Parallel-Group Study with Quetiapine Extended Release as Comparator to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy (Janssen); An Open-label, Long-term, Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants with Major Depressive Disorder (MDD) (Janssen); A Randomized, Double-blind, Multicentre, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy; A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNR (Janssen). He is UK Chief Investigator for the following studies: Novartis MDD study no. MIJ821A12201; Compass; and the COMP006 and COMP007 studies. Grant funding (past and present) includes: NIMH (USA); CIHR (Canada); NARSAD (USA); the Stanley Medical Research Institute (USA); MRC (UK); the Wellcome Trust (UK); the Royal College of Physicians of Edinburgh; the British Medical Association (UK); the VGH & UBC Foundation (Canada); WEDC (Canada); the CCS Depression Research Fund (Canada); the Michael Smith Foundation for Health Research (Canada); NIHR (UK). Janssen (UK) and EU Horizon 2020. He is the Editor of the Journal of Psychopharmacology and Deputy Editor of BJPsych Open. He has no shareholdings in pharmaceutical companies. S.S. reports the following competing interests: research grant funding on behalf of the University of Texas Health Science Center at Houston from Flow Neuroscience; paid advisory boards for the following companies: Worldwide Clinical Trials and Inversago; and Vicore Pharma. He is a full-time employee of Intra-Cellular Therapies. He has received grants and research support from NIMH (USA) (no. 1R21MH119441-01A1), NIMH (no. 1R21MH129888-01A1), NICHD (no. 1R21HD106779-01A1), SAMHSA (no. 6H79FG000470-01M003) and Fizer foundation. He has received research funding as a principal investigator or study/subinvestigator from or participated as consultant/speaker for Flow Neuroscience, COMPASS Pathways, LivaNova, Janssen, Relmada and the Psychiatry Education Forum. Intra-Cellular Therapies or National Institutes of Health (NIH) or SAMHSA or any other organizations had no role in study design and conduct; the collection, management, analysis and interpretation of the data; the preparation, review or approval of the manuscript; and the decision to submit the manuscript for publication. The study’s content is solely the responsibility of the authors and does not necessarily represent the official views of the Intra-Cellular Therapies or NIH or SAMHSA. R.M-V. has received consulting fees from Eurofarma Pharmaceuticals, Abbott and BioStrategies group; has research contracts with Boerhinger Ingelheim and Janssen Pharmaceuticals; and has received speaker fees from Otsuka, EMS and Cristalia. He is a member of the scientific boards of Symbinas Pharmaceuticals and Allergan. He is also the principal investigator for the following grants: NIH (nos. R21HD106779 and R21MH129888), Milken Institute (no. BD-0000000081). D.M. and L.H. work for Biomedical Statistical Consulting; they provide statistical support to MCRA and received payments from Flow Neuroscience. A.-R.G.-N., G.S., H.H., J.C.S., M.R., N.L., P.J.L., P.O., R.D.W. and S.S.K. declare no competing interests."

What is this Flow Neuroscience we keep hearing about? It is a manufacturer of a head-zapping device marketed as an aid for depression -- exactly the type of device being promoted by this poorly designed and unconvincing study. We should not expect scientists taking lots of money from some manufacturer to produce unbiased studies evaluating a device of such a manufacturer. 

Under the assumptions of materialism, the idea that you could improve your health by zapping your brain with electricity or magnetism makes no sense. Under the assumptions of materialists, we might expect that zapping your brain might disrupt the "delicate brain mechanism of memory storage" that materialists believe in.  Luckily such devices probably don't harm your memories, because such memories  are not actually stored in your brain.  It is ironic for neuroscientists to be promoting devices doing brain-zapping that make no sense under the assumptions of such neuroscientists.  Maybe when they promote such devices, somehow they are recalling the utter failure of neuroscientists to present a credible theory of brain memory storage or brain instant recall, and the utter failure of neuroscientists to find any trace of learned human knowledge by microscopic examination of brain tissue. 

neuroscientist conflict of interest
They are "in bed with each other"

Postscript: A slightly different method uses alternate current rather than direct current, and is called Transcranial Alternate Current Stimulation or tACS.  A year 2025 review paper states, " Overall, tACS has minimal impact on working memory improvement, but it shows potential under certain conditions. "

Tuesday, April 8, 2025

An Increase in Candid Confessions May Indicate an Ideological Regime Is Losing Support

 To describe a particular system of belief that gained some ascendancy,  we may use the term "ideological regime."  An ideological regime is some structure of belief and related social structures and habits that have become popular in a particular place.  In a particular country there may exist more than one ideological regime.  For example, in the United States there are currently multiple ideological regimes, such as these:

(1) the belief tradition and social structure of Catholicism;

(2) the belief tradition and social structures of Protestantism, taking several different forms;

(3) the belief tradition and social structures of Darwinist materialism;

(4) the belief tradition and social structures of what we may call money-centered consumerist capitalism.

In some countries,  there may be fewer ideological regimes: three, two, or rarely a single one. Looking at medieval or ancient history, we can probably find some cases in which religious beliefs were thoroughly entangled with political and economic beliefs, and in such countries there may have existed as few as only one ideological regime. 

An ideological regime consists of  both a system of belief and a social structure that supports such a system, making sure that it preserves its ascendancy, along with rules, traditions, customs or laws that help propagate the ideological regime. An ideological regime almost invariably has authorities that profess its belief doctrines. In some ideological regimes, such authorities may exist in a hierarchical order. In the Catholic Church there is a pope ruling over cardinals ruling over bishops ruling over priests.  In the ideological regime of Darwinist materialism, there is not a very formal hierarchical structure of authorities. But informally there is such a hierarchy, consisting of four levels:

(1) Nobel Prize laureates at the top of the hierarchy;

(2) professors from the most prestigious universities on the second level;

(3) professors from less prestigious colleges or universities at the third level;

(4) mere PhD holders who are not yet professors at the lowest level of authority. 

The dogmas of an ideological regime are the debatable beliefs that the regime perpetuates. Under some ideological regimes, particularly openly religious ones, there may be a frank admission that articles of faith are being taught by the regime, and that an act of faith is required to accept such doctrines.  Under other ideological regimes,  there may be claims or pretentions that the dogmas of the regime are facts that any reasonable and well-educated person should accept. 

For example, under the ideological regime of Darwinist materialism, various unproven claims about human origins or human brains may be sold as "facts of science," such as the dogma that the human mind is a product of the brain.  Under the ideological regime of Marxist-Leninism, various unproven dogmas about communism and class struggle were not described as dogmas or tenets, but were instead described as "facts of history" or "facts of economic science" that required belief from any reasonable scholar.  Under the ideological regime of money-centered consumerist capitalism, various assumptions may simply be taken for granted as rather obvious truths, such as the assumption that working 50 or 60 hour weeks at a job you don't like is well worth it if this allows you to buy some larger-than-you-need house that will cause your friends to be envious.  

The maintenance and preservation of an ideological regime requires the participation of many agents acting to perpetuate the regime.  The existence of esteemed regime authorities is not sufficient to achieve such an end. There usually must be various less prestigious  individuals who act to promulgate the teachings of the ideological regime, and possibly help punish and diminish any who dare to oppose its teachings. In the Catholic Church an example of such regime enforcers are nuns, deacons and Sunday school teachers, who lack the authority of priests, but do a great deal of the low-level indoctrination that helps to enforce the ideological regime. 

In the ideological regime of Darwinist materialism, skeptics act as regime enforcers. The skeptics act to defame and disparage any of the very many people who report observations contrary to the reigning dogmas of Darwinist materialism, such as those who report inexplicable psychic experiences or apparition sightings or extrasensory perception.  In this regime other low-level regime enforcers or regime enablers are people such as high school biology teachers, who make sure that children are indoctrinated in the belief tenets of the ideological regime, and science journalists.

In the modern landscape of Darwinist materialism, science journalists tend to uncritically parrot whatever claims or speculations come down from professors in support of their belief dogmas, even when they are far-fetched claims such as monkeys rafting across the Atlantic ocean millions of years ago.  Such journalists are also careful to write articles that restate the belief doctrines of the ideological regime of Darwinist materialism, and are careful to write little or nothing about observations in conflict with the teachings of such an ideological regime.  In the ideological regime of Marxist-Leninism, there were innumerable low-level enforcers, such as censors, local informers who snitched on dissident thinkers, and the gulag guards who helped to keep dissidents locked up in prison camps.  In the ideological regime of money-centered consumerist capitalism,  regime enablers include a host of pitchmen and social media sources that try to make you feel unworthy or second-class if you are are not consuming and purchasing as expensively as more high-spending people of a similar age. 

For an ideological regime to persist in a dominant manner, it is very important that information be carefully controlled. There are various techniques used to insure control. One technique is the publication of impressive-looking volumes or sets of volumes teaching no viewpoint other than the ideology and belief traditions of the ideological regime. For example, the ideological regime of Catholicism published the 15-volume Catholic Encyclopedia which was followed many years later by the 15-volume New Catholic Encyclopedia; and the ideological regime of Marxist-Leninism published an equally impressive-looking 65-volume set called the Great Soviet Encyclopedia. For decades the ideological regime of Darwinist materialism was promoted by the many volumes of the Encyclopedia Britannica and the World Book encyclopedia, which would describe many unproven claims as if they were facts. Nowadays wikipedia.org has largely replaced such encyclopedias, and serves as the chief party organ of Darwinist materialism.  Similar to such encyclopedias are subject textbooks and journals in which you are indoctrinated in strict accordance to some ideological regime.  

In such encyclopedias and textbooks and journals there is almost always a rigorous filtration and control of information, so that the reader gets no information that might disturb his faith in the ideological regime served by the encyclopedia or textbook or journal.  So, for example, you will read nothing in the Catholic Encyclopedia that might shake your faith in Catholicism, and there was nothing in the Great Soviet Encyclopedia that would shake your faith in Marxism-Leninism.  And on wikipedia.org, you will almost never read anything that shakes your faith in the belief doctrines of Darwinist materialism.  When such information sources discuss phenomena or viewpoints that conflict with the ideological regime they serve, any discussion will be carefully controlled so that mainly  negative information will be served up about the opposing viewpoint or the inconvenient phenomena.  

Darwinist authoritarianism
                                An indoctrination center of an ideological regime

When either a political regime or an ideological regime has complete information control, you will see it asserting its claims with the most dogmatic certainty. There will be no confessions of any major problems. For example, let us imagine an incompetent political regime led by a dictator, one in which 5% of the people are starving. If the regime has a perfect control over information, the newspapers may read something like this:

"Our glorious leader's success is shown in the wonderful happiness of our citizens.  All of them are so happy to be living in the paradise of prosperity that has resulted from the wise decisions of our brilliant leader."  

But if the regime has something less than perfect control over information, you might read something like this in the newspapers of the country in which 5% of the people are starving:

"Our glorious leader is doing a wonderful job of preserving the health of our citizens.  You may have heard rumors that some people are starving. Do not believe such lies! They are spread by scoundrels trying to disrupt society."  

But if the stranglehold of the regime starts to weaken even further,  you might read something like this in the newspapers of the country in which 5% of the people are starving: 

"It has become apparent that due to some temporary problem, many people are starving. But there is good news!  Our glorious leader is working hard on solving this problem. Because he is such a brilliant genius, no doubt the hunger problem will soon be solved."

And if the stranglehold of the regime starts to weaken even further,  you might read something like this in the newspapers of the country in which 5% of the people are starving: 

"It has become apparent that many people in our country are starving.  Our leader is working hard on solving this problem. It is hoped that he will be very successful in fixing this very bad problem."

And if the stranglehold of the regime starts to weaken even further,  you might read something like this in the newspapers of the country in which 5% of the people are starving: 

"Everyone is lamenting that so many people in our country are starving.  Our leader is working hard to try to solve this problem. Some are hopeful he will succeed. But others seem to be pessimistic about the actions he is attempting."

Once the newspapers of the regime start running stories as candid as the one above, the regime may be close to collapse. The examples above illustrate the idea that the more confessions we get in the press about the failures of a regime (whether political or ideological), and the more candid such confessions are, the closer such a regime may be to collapse or decline. 

In the early stages of the decline of an ideological regime, it will still be too dangerous in public discourse to flatly state that the regime is misguided or on the wrong track. But it may become permissible to make partial confessions that inform about some way in which the regime has failed. The weaker that the regime becomes, the more such confessions will appear, and the more candid such confessions will be. 

The ideological regime of Darwinist materialism still exerts a pernicious stranglehold over discussions of matters such as human minds and human origins. But there are signs such a stranglehold may be weakening. We are starting to see more and more confessions by scientists about explanatory failures of such an ideological regime. Such confessions are typically partial confessions in which someone will not say something very broad such as "we scientists are on the wrong track" or "some of our basic assumptions are false," but instead say some limited confession about some type of explanatory failure. Below are some examples:

  • "Despite substantial efforts by many researchers, we still have no scientific theory of how brain activity can create, or be, conscious experience.” -- Donald D. Hoffman Department of Cognitive Sciences University of California, "Conscious Realism and the Mind-Body Problem."
  • "Little progress in solving the mystery of human cognition has been made to date." -- 2 neuroscientists, 2021 (link). 
  • “To sum up, it can be said that when it comes to answering the question of how information is carried forward in time in the brain we remain largely clueless.” --  Cognitive scientist Patrick C. Trettenbrein, "The Demise of the Synapse As the Locus of Memory" (link). 
  • " We don't know how a brain produces a thought." -- Neuroscientist Saskia De Vries (link). 
  • "You realize that neither the term ‘decision-making’ nor the term ‘attention’ actually corresponds to a thing in the brain." -- neuroscentist Paul Ciskek (link). 
  • "We know very little about the brain. We know about connections, but we don't know how information is processed." -- Neurobiologist Lu Chen. 
  • "Computers really do operate on symbolic representations of the world. They really store and retrieve. They really process. They really have physical memories. They really are guided in everything they do, without exception, by algorithms. Humans, on the other hand, do not — never did, never will. Given this reality, why do so many scientists talk about our mental life as if we were computers?" -- Senior research psychologist Robert Epstein.
  • "The neuroscientific study of creativity is stuck and lost." -- Psychologist Arne Dietrich,  "Where in the brain is creativity: a brief account of a wild-goose chase."
  • "How creative ideas arise in our mind and in our brain is a key unresolved question." -- nine scientists (link).
  • "The central dogma of Neuormania is that persons are their brains....Basic features of human experience...elude neural explanation. Indeed, they are at odds with the materialist framework presupposed in Neuromania. Many other assumptions of Neuromania -- such as that the mind-brain is a computer -- wilt on close inspection. All of this notwithstanding, the mantra 'You are your brain' is endlessly repeated. This is not justified by what little we know of the brain, or more importantly, of the relationship between our brains and ourselves as conscious agents."  -- Raymond Tallis, Professor of Geriatric Medicine, University of Manchester, "Aping Mankind," page xii (link). 
  • "And so we are forced to a conclusion opposite to the one drawn earlier: that consciousness cannot be due to activity in the brain and that cerebral activity is an inadequate explanation of mental activity."  -- Raymond Tallis, Professor of Geriatric Medicine, University of Manchester, "Brains and Minds: A Brief History of Neuromythology" (link). 
  • "My own view of a secular universe, devoid of consciousness and intelligence 'beyond the brain' (Grof 1985) gave way little by little over several decades and now seems quite absurd." -- John Mack MD, Harvard professor of psychology (link). 
  • "The passage from the physics of the brain to the corresponding facts of consciousness is unthinkable. Were we able even to see and feel the very molecules of the brain, and follow all their motions, all their groupings, all their electric discharges if such there be, and intimately acquainted with the corresponding states of thought and feeling, we should be as far as ever from the solution of the problem,...The chasm between the two classes of phenomena would still remain intellectually impassable."  -- Physicist John Tyndall (link).
  • "Many who work within the SMC [standard model of consciousness] assume that a nervous system is necessary and sufficient for an existential consciousness. While this is a common stance...we have yet to see a coherent defense of this proposition or a well-developed biomolecular argument for it. For most, it is simply a proclamation. Moreover, we have not seen any effort to identify what features of neural mechanisms 'create' consciousness while non-neural ones cannot. This too is simply a pronouncement." -- Four scientists, "The CBC theory and its entailments," (link).
  • "Direct evidence that synaptic plasticity is the actual cellular mechanism for human learning and memory is lacking." -- 3 scientists, "Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?" 
  • "The fundamental problem is that we don't really know where or how thoughts are stored in the brain. We can't read thoughts if we don't understand the neuroscience behind them." -- Juan Alvaro Gallego, neuroscientist. 
  • "The search for the neuroanatomical locus of semantic memory has simultaneously led us nowhere and everywhere. There is no compelling evidence that any one brain region plays a dedicated and privileged role in the representation or retrieval of all sorts of semantic knowledge."  Psychologist Sharon L. Thompson-Schill, "Neuroimaging studies of semantic memory: inferring 'how' from 'where' ".
  • "How the brain stores and retrieves memories is an important unsolved problem in neuroscience." --Achint Kumar, "A Model For Hierarchical Memory Storage in Piriform Cortex." 
  • "We are still far from identifying the 'double helix' of memory—if one even exists. We do not have a clear idea of how long-term, specific information may be stored in the brain, into separate engrams that can be reactivated when relevant."  -- Two scientists, "Understanding the physical basis of memory: Molecular mechanisms of the engram."
  • "There is no chain of reasonable inferences by means of which our present, albeit highly imperfect, view of the functional organization of the brain can be reconciled with the possibility of its acquiring, storing and retrieving nervous information by encoding such information in molecules of nucleic acid or protein." -- Molecular geneticist G. S. Stent, quoted in the paper here. 
  • "Up to this point, we still don’t understand how we maintain memories in our brains for up to our entire lifetimes.”  --neuroscientist Sakina Palida.
  • "The available evidence makes it extremely unlikely that synapses are the site of long-term memory storage for representational content (i.e., memory for 'facts'’ about quantities like space, time, and number)." --Samuel J. Gershman,  "The molecular memory code and synaptic plasticity: A synthesis."
  • "Synapses are signal conductors, not symbols. They do not stand for anything. They convey information bearing signals between neurons, but they do not themselves convey information forward in time, as does, for example, a gene or a register in computer memory. No specifiable fact about the animal’s experience can be read off from the synapses that have been altered by that experience.” -- Two scientists, "Locating the engram: Should we look for plastic synapses or information- storing molecules?
  • " If I wanted to transfer my memories into a machine, I would need to know what my memories are made of. But nobody knows." -- neuroscientist Guillaume Thierry (link). 
  • "Memory retrieval is even more mysterious than storage. When I ask if you know Alex Ritchie, the answer is immediately obvious to you, and there is no good theory to explain how memory retrieval can happen so quickly." -- Neuroscientist David Eagleman.
  • "How could that encoded information be retrieved and transcribed from the enduring structure into the transient signals that carry that same information to the computational machinery that acts on the information?....In the voluminous contemporary literature on the neurobiology of memory, there is no discussion of these questions."  ---  Neuroscientists C. R. Gallistel and Adam Philip King, "Memory and the Computational Brain: Why Cognitive Science Will Transform Neuroscience,"  preface. 
  • "The very first thing that any computer scientist would want to know about a computer is how it writes to memory and reads from memory....Yet we do not really know how this most foundational element of computation is implemented in the brain."  -- Noam Chomsky and Robert C. Berwick, "Why Only Us? Language and Evolution," page 50. 
  • "When we are looking for a mechanism that implements a read/write memory in the nervous system, looking at synaptic strength and connectivity patterns might be misleading for many reasons...Tentative evidence for the (classical) cognitive scientists' reservations toward the synapse as the locus of memory in the brain has accumulated....Changes in synaptic strength are not directly related to storage of new information in memory....The rate of synaptic turnover in absence of learning is actually so high that the newly formed connections (which supposedly encode the new memory) will have vanished in due time. It is worth noticing that these findings actually are to be expected when considering that synapses are made of proteins which are generally known to have a short lifetime...Synapses have been found to be constantly turning over in all parts of cortex that have been examined using two-photon microscopy so far...The synapse is probably an ill fit when looking for a basic memory mechanism in the nervous system." -- Scientist Patrick C. Trettenbrein, "The Demise of the Synapse As the Locus of Memory: A Looming Paradigm Shift? (link).
  • "Most neuroscientists believe that memories are encoded by changing the strength of synaptic connections between neurons....Nevertheless, the question of whether memories are stored locally at synapses remains a point of contention. Some cognitive neuroscientists have argued that for the brain to work as a computational device, it must have the equivalent of a read/write memory and the synapse is far too complex to serve this purpose (Gaallistel and King, 2009; Trettenbrein, 2016). While it is conceptually simple for computers to store synaptic weights digitally using their read/write capabilities during deep learning, for biological systems no realistic biological mechanism has yet been proposed, or in my opinion could be envisioned, that would decode symbolic information in a series of molecular switches (Gaallistel and King, 2009) and then transform this information into specific synaptic weights." -- Neuroscientist Wayne S. Sossin (link).
  • "We take up the question that will have been pressing on the minds of many readers ever since it became clear that we are profoundly skeptical about the hypothesis that the physical basis of memory is some form of synaptic plasticity, the only hypothesis that has ever been seriously considered by the neuroscience community. The obvious question is: Well, if it’s not synaptic plasticity, what is it? Here, we refuse to be drawn. We do not think we know what the mechanism of an addressable read/write memory is, and we have no faith in our ability to conjecture a correct answer."  -- Neuroscientists C. R. Gallistel and Adam Philip King, "Memory and the Computational Brain Why Cognitive Science Will Transform Neuroscience."  page Xvi (preface). 
  • "Current theories of synaptic plasticity and network activity cannot explain learning, memory, and cognition."  -- Neuroscientist Hessameddin AkhlaghpourÆš (link). 
  • "We don’t know how the brain stores anything, let alone words." -- Scientists David Poeppel and, William Idsardi, 2022 (link).
  • "If we believe that memories are made of patterns of synaptic connections sculpted by experience, and if we know, behaviorally, that motor memories last a lifetime, then how can we explain the fact that individual synaptic spines are constantly turning over and that aggregate synaptic strengths are constantly fluctuating? How can the memories outlast their putative constitutive components?" --Neuroscientists Emilio Bizzi and Robert Ajemian (link).
  • "After more than 70 years of research efforts by cognitive psychologists and neuroscientists, the question of where memory information is stored in the brain remains unresolved." -- Psychologist James Tee and engineering expert Desmond P. Taylor, "Where Is Memory Information Stored in the Brain?"
  • "There is no such thing as encoding a perception...There is no such thing as a neural code...Nothing that one might find in the brain could possibly be a representation of the fact that one was told that Hastings was fought in 1066." -- M. R.  Bennett, Professor of Physiology at the University of Sydney (link).
  • "No sense has been given to the idea of encoding or representing factual information in the neurons and synapses of the brain." -- M. R. Bennett, Professor of Physiology at the University of Sydney (link).
  • ""Despite over a hundred years of research, the cellular/molecular mechanisms underlying learning and memory are still not completely understood. Many hypotheses have been proposed, but there is no consensus for any of these."  -- Two scientists in a 2024 paper (link). 
  • "We have still not discovered the physical basis of memory, despite more than a century of efforts by many leading figures. Researchers searching for the physical basis of memory are looking for the wrong thing (the associative bond) in the wrong place (the synaptic junction), guided by an erroneous conception of what memory is and the role it plays in computation." --Neuroscientist C.R. Gallistel, "The Physical Basis of Memory," 2021.
  • "To name but a few examples, the formation of memories and the basis of conscious  perception, crossing  the threshold  of  awareness, the  interplay  of  electrical  and  molecular-biochemical mechanisms of signal transduction at synapses, the role of glial cells in signal transduction and metabolism, the role of different brain states in the life-long reorganization of the synaptic structure or  the mechanism of how  cell  assemblies  generate a  concrete  cognitive  function are  all important processes that remain to be characterized." -- "The coming decade of digital brain research, a 2023 paper co-authored by more than 100 neuroscientists, one confessing scientists don't understand how a brain could store memories. 
  • "The human brain isn’t really empty, of course. But it does not contain most of the things people think it does – not even simple things such as ‘memories’....We don’t create representations of visual stimuli, store them in a short-term memory buffer, and then transfer the representation into a long-term memory device. We don’t retrieve information or images or words from memory registers. Computers do all of these things, but organisms do not." -- Robert Epstein,  senior research psychologist, "The Empty Brain." 
  • Yet while these are several examples of well-understood processes, our study of animal morphogenesis is really in its infancy." -- David Bilder and Saori L. Haigo1, "Expanding the Morphogenetic Repertoire: Perspectives from the Drosophila Egg." 
  • "Fundamentally, we have a poor understanding of how any internal organ forms." -- Timothy Saunders, developmental biologist (link).
  • "Biochemistry cannot provide the spatial information needed to explain morphogenesis...Supracellular morphogenesis is mysterious...Nobody seems to understand the origin of biological and cellular order."  -- Six medical authorities (link).  
  • The majority of cellular proteins function as subunits in larger protein complexes. However, very little is known about how protein complexes form in vivo." Duncan and Mata, "Widespread Cotranslational Formation of Protein Complexes," 2011.
  • "While the occurrence of multiprotein assemblies is ubiquitous, the understanding of pathways that dictate the formation of quaternary structure remains enigmatic." -- Two scientists (link). 
  • "A general theoretical framework to understand protein complex formation and usage is still lacking." -- Two scientists, 2019 (link). 
  • "Protein assemblies are at the basis of numerous biological machines by performing actions that none of the individual proteins would be able to do. There are thousands, perhaps millions of different types and states of proteins in a living organism, and the number of possible interactions between them is enormous...The strong synergy within the protein complex makes it irreducible to an incremental process. They are rather to be acknowledged as fine-tuned initial conditions of the constituting protein sequences. These structures are biological examples of nano-engineering that surpass anything human engineers have created. Such systems pose a serious challenge to a Darwinian account of evolution, since irreducibly complex systems have no direct series of selectable intermediates, and in addition, as we saw in Section 4.1, each module (protein) is of low probability by itself." -- Steinar Thorvaldsen and Ola Hössjerm, "Using statistical methods to model the fine-tuning of molecular machines and systems,"  Journal of Theoretical Biology.
  • "In real time how the chaperones fold the newly synthesized polypeptide sequences into a particular three-dimensional shape within a fraction of second is still a mystery for biologists as well as mathematicians."   -- Arun Upadhyay, "Structure of proteins: Evolution with unsolved mysteries," 2019.
  • "The problem of protein folding is one of the most important problems of molecular biology. A central problem (the so called Levinthal's paradox) is that the protein is first synthesized as a linear molecule that must reach its native conformation in a short time (on the order of seconds or less). The protein can only perform its functions in this (often single) conformation. The problem, however, is that the number of possible conformational states is exponentially large for a long protein molecule. Despite almost 30 years of attempts to resolve this paradox, a solution has not yet been found." -- Two scientists, "On a generalized Levinthal's paradox," 2018. 
  • "A wide variety of protein structures exist in nature, however the evolutionary origins of this panoply of proteins remain unknown."  -- Four Harvard scientists, "The role of evolutionary selection in the dynamics of protein structure evolution." 
  • "The past three decades have shown that psychiatry’s medical vision is neither scientifically credible nor morally sound." -- Justin Garson, professor of philosophy at Hunter College (link).
  •  "But when it comes to our actual feelings, our thought, our emotions, our consciousness, we really don't have a good answer as to how the brain helps us to have those different experiences." -- Andrew Newberg, neuroscientist, Ancient Aliens, Episode 16 of Season 14, 6:52 mark. 
The quotes above are from the very large collection of similar quotes I have in my long post "Candid Confessions of the Scientists" you can read here. Many such confessions have been made, and they may be increasing in number and intensity.  The more such confessions appear, and the more severe the confessions are, the more we should tend to suspect that the stranglehold of Darwinist materialism is weakening, and that this ideological regime is "on the ropes." 

toppling scientific theory


problems with materialism


Friday, October 27, 2023

How the Academia-Cyberspace-Pharmaceutical-Biotech-Publishing Complex Incentivizes Bad Brain Research

Countless times on this blog, I have discussed poor quality research about brains. An interesting question to ponder is: why is there so much bad research done about brains? Why do we see so many studies guilty of Questionable Research Practices such as way-too-small study group sizes and a lack of blinding protocols? Why do many scientific papers make claims about their observations that are not justified by any observations reported in the paper? Why do we have so many misleading stories in the press claiming that some brain research showed something that it did not actually show?

In my previous post "Why the Academia Cyberspace Profit Complex Keeps Giving Misleading Brain Research" I made a fairly good start at answering such questions. I identified a social network I called the academia cyberspace profit complex, and I explained some of the reasons why that complex incentivizes poor quality but interesting-sounding brain research.  Among the factors I identified were these:

  • Professors tend to be judged these days by the "easy-to-quantify" metrics of the number of papers they have written or co-written, and the number of citations such papers get, rather than a "hard-to-quantify" metric of  the quality of the research procedures they followed. 
  • The more "quick and dirty" studies scientists publish (studies that are relatively easy to produce, but do not involve very high standards of research quality), the higher a "papers published count" a scientist will have. 
  • Scientific journals these days have a high bias called "publication bias," a tendency to prefer to publish papers reporting some supposed "positive effect" supposedly involving some causal relation rather than a null result reporting no such causal relation. 
  • The more interesting-sounding or important-sounding a paper may be, the greater the likelihood that it will be cited by other scientists, and the higher the "citation count" of the scientist authors will be. 
  • The desire to produce interesting-sounding or important-sounding papers reporting "positive effects" rather than null results tends to bias the way papers are written and the way studies are designed and performed, creating an incentive for study designs likely to end up with some "positive result" rather than a null result.  Among the resulting effects is often "cherry picking" of data, so that the paper ends up with a "publishable" positive effect rather than a null result.
  • Once a study has been published in a scientific journal, it is announced to the public by means of a university press release or college press release. Nowadays university press offices are notorious for their hype and exaggeration, and routinely make interesting-sounding claims about new research that are not justified by the observations in the scientific paper being announced.  An abundance of such hype helps to glorify universities, keep them in the public's eyes, and helps to justify the very high tuition rates of universities. Misstatements in press releases come both from press office copywriters who are encouraged to glorify and hype new research, but also from scientists quoted in the press releases, who often make unwarranted or false claims about their own research, in an effort to maximize the attention such research will get. 
  • There is nowadays an extremely large cyberspace industry that has an incentive to uncritically parrot university press releases, and an additional incentive to further exaggerate and hype the results reported by such press releases.  The incentive comes in the form of web pages containing ads that generate revenue for the owners of web pages.  So we see an enormous "clickbait" effect, in which sensational-sounding headlines appear on web pages, with the headlines being hyperlinks that take the reader to a page filled with ads.  Every time a page with such ads is viewed, money is generated for the owner of the web site.  The "clickbait" headlines often take you to pages discussing research that never justifies the sensational clickbait headline. For example, you may see on some web page a headline "Scientists Make Giant Leap in Understanding Memory." Clicking on that headline will typically take you to some story about merely another very poorly designed study using mice, something that is no actual progress in understanding memory. 
  • "Quick and dirty" scientific research helps science journalists fill their quotas of science stories. Knowing that web sites prefer to publish stories with sensational-sounding headlines, science journalists are incentivized to "go with the hype" rather than critically discussing poorly designed research. 
  • The increase in "papers published" counts and citation counts resulting from "quick and dirty" research helps scientists meet paper count quotas and citation quotas that may be informally required for their promotion or advancement, and increases their chances of getting profit from things such as book deals and consulting contracts. 

My previous post discussed many of the factors that incentivize poorly designed and executed scientific research. But I left out a discussion of several very important additional factors:

  • Nowadays pharmaceutical companies may have a very large incentive to fund and/or promote poorly designed and executed brain research, particularly whenever such research helps to promote some pill that such companies sell. The mental health  pharmaceutical industry is estimated to be a 36 billion dollar industry. 
  • Nowadays biotech companies may have a very large incentive to fund and/or promote poorly designed and executed brain research, particularly whenever such research helps to promote some device that such companies sell. Biotech companies include very many companies such as the manufacturers of MRI devices, the manufacturers of EEG equipment, the manufacturers of implantable medical devices, and the manufacturers of noninvasive brain-related devices that a person may put on his head. The biotech industry is a trillion-dollar industry, and many billions of that involves brain-related products. 
  • Nowadays the publishers of scientific papers have a very large incentive to publish poorly designed and executed brain research, simply because a profusion of such "quick and dirty" papers means more available newly written papers that can be published. The more papers published, the more journals can be published, and the more journal subscription fees can be charged.  According to one site, "The worldwide revenue from academic publishing stands at over $19 billion per year," and that "out of this figure, over 50% is attributed to 5 major publishing companies – Elsevier, John Wiley & Sons, Taylor & Francis, Springer Nature, and SAGE."
  • Scientists doing brain research often have conflicts of interest, such as the ownership of shares of corporations that may increase in value if the research reports a particular type of result, or something like a relationship in which the scientists get consulting fees from some corporation whose fate may be affected by the research they are doing. 
  • Nowadays much of brain-related research is funded largely or mainly by private corporations interested in having the research find some particular result. 
  • The relationship between private industry and brain-related research is so strong that many scientific papers are essentially "ghost written" by anonymous employees of corporations standing to benefit if the research reports a particular result. 

To diagram these complex relations and financial motivations, I must present a diagram much larger than the relation diagram that I presented in my earlier post. The revised diagram is below:

who profits from bad research

The diagram shows a complex stream of profits that results from scientists starting out by doing "quick and dirty" poorly designed research.  The result is a set of winners and losers.  

The Winners

These are the winners from "quick and dirty" brain-related research:

  • The scientists who get some additional paper with their name on it to increase their "papers published" count, and also may get some more of the highly coveted paper citations. Many of these scientists are heavy investors in pharmaceutical companies or biotech companies (or recipients of income from such sources), and indirectly profit when such companies profit in the ways described below. 
  • The universities who can announce important-sounding research by some exaggerating press release, thereby helping to maintain their prominent public profile, and their reputation as a center of "cutting edge" research. 
  • The science journalists who get some new sensational-sounding press release that they can use as the basis for some interesting-sounding article that will help them fill their quota of articles written. 
  • The owners of web pages that will announce the results using clickbait headlines leading to pages containing ads that generate money for the people running the web sites. 
  • The pharmaceutical companies that may benefit when a specific product of theirs is favorably mentioned by the new scientific paper, and who also in general benefit when literature keeps people thinking that brains are the source of our minds and our mental problems, and keeps people thinking that the way to solve psychological problems is by taking pills. 
  • The biotech device  companies that may benefit when a specific product of theirs is favorably mentioned by the new scientific paper, and who also in general benefit when literature keeps people thinking that brains are the source of our minds and our mental problems, and keeps people thinking that brain-related devices can help solve mental problems or mood problems. 
  • The publishers of expensive scientific journals, who can meet their monthly quotas of papers to be published (for such publishers it is financially better for there to be written in any month 800 poorly-written papers describing poorly designed papers and 200 well-written papers describing well-designed papers, than for there to be written in the same month 100 poorly-written papers describing poorly designed papers and 300 well-written papers describing well-designed papers).

The Losers

These are the losers from "quick and dirty" brain-related research:

  • All the people in the general public, who keep being misled by "science news" headlines giving them the wrong idea about the source of their minds and the storage place of their memories, and who keep reading research reports which give them the wrong idea that they are mere brains rather than souls, minds or spirits. The resulting psychological, moral and spiritual harm is enormous but incalculable. 
  • Very many people with psychological problems or emotional problems or learning problems who are given the wrong idea that the way to help such problems is by fiddling with brains or brain chemistry, rather than by improving education techniques and educational literature, improving access to education and counseling,  improving social conditions, improving social justice, improving family relations or improving worldviews and positive attitudes about selves by properly educating people so that they learn about the most important facts and observations related to who they are and how they got here. 
In a classic essay, the distinguished military officer Smedley Butler stated this: "War is a racket...It is conducted for the benefit of the very few, at the expense of the very many." It is true to say exactly that about junk science research.  The production of such research is a racket, for the benefit of the few beneficiaries listed above, at the expense of everyone else. 

Long story short, if you want to know why so much junk research gets published about brains, follow the money and ponder who profits. But it would be an oversimplification to suggest that financial interests and career advancement offers a full explanation for why we see so much bad brain-related research and so much bad reporting about such research. Another important factor is that poorly-designed, poorly-executed and poorly-described research relating to brains helps to provide what can be regarded as belief system justification. We should not forget that those behind such research are members of a belief community with cherished dogmas that they keep claiming are facts but which are very much unproven, such as the dogma that your brain produces your mind and thinking, and the dogma that your brain stores your beliefs and memories.  Members of such a community get a non-financial mental reward whenever there appears research which they can claim as evidence their beliefs are correct. In cases when unfounded beliefs are held and cherished,  poorly-designed poorly-executed and inaccurately-described research can provide a comforting feeling of assurance that well-designed well-executed and accurately-described research might never be able to provide.