The Groundless Myth of Superagers Growing More Brain Cells

 Never forget there's a "profess" in the word "professor."  And "profess" is defined as "to affirm one's faith in or allegiance to (a religion or set of beliefs)."  A recent press release from the rather strangely named University of Illinois Chicago gives us an example of a neuroscientist professor professing, and incorrectly boasting about grand things that were not at all done. 

We have a headline of "What makes superagers’ brains special?"  So-called superagers are very old people with very good memories. The press release attempts to suggest the story line that these superagers can remember better because they had higher rates of neuron creation (neurogenesis).  It's a story line that fits in with the idea that brains store memories. But it's not a story line backed up by any good evidence. 

Neurons are created before humans reach adulthood. But there is no robust evidence that significant number of neurons are created in adulthood. 

In the UIC press release we have this extremely glaring example of a scientist crowing about some grand and glorious result, when the research is actually very low-quality research because of its use of way-too-small study group sizes.  The press release says this:

" 'This is a big step forward in understanding how the human brain processes cognition, forms memories and ages. Determining why some brains age more healthily than others can help researchers make therapeutics for healthy aging, cognitive resilience and the prevention of Alzheimer’s disease and related dementia,' said Orly Lazarov, a professor in UIC’s College of Medicine and director of the Alzheimer’s Disease and Related Dementia Training Program."

But the truth is that we have here neither a  "big step forward" nor an example of a decently done scientific study. The reason is the tiny study group sizes, which were only 8 subjects per study group. 

When we look at the scientific paper "Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease," and search for the study group size (using the search phrase "n=") we find that the study group sizes were only 8 subjects per study group. No study like this should be taken seriously unless it used a study group size of at least 15 or 20 subjects per study group. 

There is simply no basis for concluding that super-agers have neuron creation rates any different from old people with poor memories, nor is there any good basis for thinking that adults create new neurons in significant numbers. No such generalization can be made with any reliability when you do a way-too-small study group size of only 8 people. 

Did the UIC press release tell us that only 8 subjects per study group were used? No, it conveniently forgot to mention how many subjects were used. 

We should note that in the text of the paper Lazarov sings a tune very different from her boasts in the press release. In the paper we read this (with "power" referring to statistical power):

"Notably, we observed a general increase in the number of immature neurons in SA; however, inter-sample variability and low sample number compromised the power of our analysis. It should be noted that the high level of variability from sample-to-sample in cell-type abundance limited the quantitative power of our study. Future experiments with a greater number of human brain samples will be needed to study this aspect in depth."

Wow, that sounds like kind of a confession of failing to do the work in a way that would inspire confidence. So why on Earth was Lazarov boasting in the press release that this study was "a big step forward in understanding how the human brain processes cognition, forms memories and ages"?  

Let us now look at some neuroscientists who have denied the doctrine of adult human neurogenesis, by denying that human adults  create new brain cells. 

• A 2018 paper states, "Our recent observations suggest that newborn neurons in the adult human hippocampus (HP) are absent or very rare (Sorrells et al., 2018)." The paper notes that "studies supporting the presence of adult human hippocampal neurogenesis are not consistent with each other: some report a sharp decline and small, negligible contribution in adults...others support continuous high levels of neurogenesis in old age (Spalding et al., 2013; Boldrini et al., 2018), but show extremely high variability."
• A 2018 paper states "2 independent papers coming from different parts of the world have used a similar approach and methodology leading to converging results and the following similar conclusions: hippocampal neurogenesis in humans decays exponentially during childhood and is absent or negligible in the adult." It says these papers "are Sorrells et al. (2018) from the lab of Alvarez-Buylla in USA published in March in Nature, and the study by Cipriani and coworkers from the Adle-Biassette’s lab in France published in this issue of Cerebral Cortex (2018; 27: 000–000)."
• A 2018 article in The American Scientist (co-authored by Sorrells and Alvarez-Buylla) is entitled "No Evidence for New Adult Neurons."  It said, "Adult human brains don’t grow new neurons in the hippocampus, contrary to the prevailing view." The authors criticize previous reports of adult neurogenesis partially by saying they "frequently used only a single protein to identify new neurons," which was a faulty technique because "we found that the protein most often used, one called doublecortin, can also be seen in nonneuronal brain cells (called glia) that are known to regenerate throughout life." A 2022 article entitled "Doublecortin and the death of a dogma" refers to work by Franjic, saying, "out of the 139,187 nuclei sequenced, only 2 showed appropriate transcriptomes for neural precursor cells... suggesting adult human neurogenesis is rare, if it occurs at all."
• A 2019 paper says that "a balanced review of the literature and evaluation of the data indicate that adult neurogenesis in human brain is improbable," and that "several high quality recent studies in adult human brain, unlike in adult brains of other species, neurogenesis was not detectable."
• A 2018 paper claimed that "New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus," but the paper's title was "Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults."
• Describing his research, the neuroscientist  Ashutosh Kumar stated in 2020 that he had found this: "Progression of neurogenesis is restricted after childhood, and reduces to negligible levels around adolescence and onwards."
• A 2022 paper was entitled "Mounting evidence suggests human adult neurogenesis is unlikely."
• A 2022 paper states, "In this review, we will assess critically the claim of significant adult neurogenesis in humans and show how current evidence strongly indicates that humans lack this trait." The paper states that "In summary, a thorough review of the literature shows that there is no scientific convincing evidence of the generation and incorporation of new neurons into the circuitry of the adult human brain, including the dentate gyrus of the hippocampus."  Noting how false claims persist within neuroscience, the paper states, "As Victor Hamburger, co-discoverer of the nerve growth factor, said at an informal meeting: 'A single report of an incorrect finding that many people like, takes more than hundreds of papers with negative findings to make an acceptable correction.' ” 
• A 2021 paper was entitled "Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus."

There is another reason for disbelieving the "superagers make more neurons" story, besides the lack of evidence for adult neurogenesis. The additional reason is that when asked to explain memory creation, neuroscientists typically appeal not to neurons but to synapses existing outside of neurons.  The senseless story that neuroscientists keep telling is that memory creation occurs by "synapse strengthening," an idea that makes no sense for a variety of reasons, including the fact that information is never stored by an act of mere strengthening, and also the fact that synapses are made up of proteins with an average lifetime 1000 times shorter than the longest length of time that humans can remember things (50 years or more). Conceivably a neuroscientist might get a talking point in favor of such a theory of synaptic memory storage if he were to show that the synapses of superagers are stronger or more abundant than the synapses of typical agers. But you would not get a talking point to support such a theory of synaptic memory storage if you merely showed that superagers created more neurons than normal agers. 

Adult Neurogenesis Claims Are a Case Study of Neuroscientists Dogmatically Asserting Dubious Claims

Do human adult brains create new brain cells or neurons? The neuroscientist belief community cannot get its story straight on this topic. Very many neuroscientists matter-of-factly claim that the brains of human adults do create new neurons, and thereby assert as fact the doctrine of adult neurogenesis. Many other neuroscientists matter-of-factly claim that the brains of human adults do not create new neurons, and thereby deny the doctrine of adult neurogenesis.

Neuroscientists Teaching the Doctrine of Adult Neurogenesis

Let us first look at some neuroscientists who have asserted the doctrine of adult human neurogenesis, by claiming that human adults do create new brain cells. 

• In a 1998 paper "Adult Neurogenesis in the Adult Human Hippocampus, one that has been cited more than 8000 times, scientists claimed "we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans," and that "Our results further indicate that the human hippocampus retains its ability to generate neurons throughout life." 
• A 2014 paper claimed, "Our findings demonstrate a unique pattern of neurogenesis in the adult human brain."
• A 2015 paper claimed that "it is now known that neurogenesis persists throughout the human lifespan, and new neurons are being formed in the adult brain."
• A 2021 paper claimed that "most published studies provide evidence for childhood and adult neurogenesis in the human brain stem cell niches."
• A 2022 paper predicted that future studies "will confirm our indications that adult human neurogenesis is orchestrated in a broad brain area."
• A 2018 paper notes that "Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions," but nonetheless says "there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan."

Neuroscientists Recently Denying the Doctrine of Adult Neurogenesis

Let us now look at some neuroscientists who have denied the doctrine of adult human neurogenesis, by denying that human adults  create new brain cells. 

• A 2018 paper states, "Our recent observations suggest that newborn neurons in the adult human hippocampus (HP) are absent or very rare (Sorrells et al., 2018)." The paper notes that "studies supporting the presence of adult human hippocampal neurogenesis are not consistent with each other: some report a sharp decline and small, negligible contribution in adults...others support continuous high levels of neurogenesis in old age (Spalding et al., 2013; Boldrini et al., 2018), but show extremely high variability."
• A 2018 paper states "2 independent papers coming from different parts of the world have used a similar approach and methodology leading to converging results and the following similar conclusions: hippocampal neurogenesis in humans decays exponentially during childhood and is absent or negligible in the adult." It says these papers "are Sorrells et al. (2018) from the lab of Alvarez-Buylla in USA published in March in Nature, and the study by Cipriani and coworkers from the Adle-Biassette’s lab in France published in this issue of Cerebral Cortex (2018; 27: 000–000)."
• A 2018 article in The American Scientist (co-authored by Sorrells and Alvarez-Buylla) is entitled "No Evidence for New Adult Neurons."  It said, "Adult human brains don’t grow new neurons in the hippocampus, contrary to the prevailing view." The authors criticize previous reports of adult neurogenesis partially by saying they "frequently used only a single protein to identify new neurons," which was a faulty technique because "we found that the protein most often used, one called doublecortin, can also be seen in nonneuronal brain cells (called glia) that are known to regenerate throughout life." A 2022 article entitled "Doublecortin and the death of a dogma" refers to work by Franjic, saying, "out of the 139,187 nuclei sequenced, only 2 showed appropriate transcriptomes for neural precursor cells... suggesting adult human neurogenesis is rare, if it occurs at all."
• A 2019 paper says that "a balanced review of the literature and evaluation of the data indicate that adult neurogenesis in human brain is improbable," and that "several high quality recent studies in adult human brain, unlike in adult brains of other species, neurogenesis was not detectable."
• A 2018 paper claimed that "New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus," but the paper's title was "Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults."
• Describing his research, the neuroscientist  Ashutosh Kumar stated in 2020 that he had found this: "Progression of neurogenesis is restricted after childhood, and reduces to negligible levels around adolescence and onwards."
• A 2022 paper was entitled "Mounting evidence suggests human adult neurogenesis is unlikely."
• A 2022 paper states, "In this review, we will assess critically the claim of significant adult neurogenesis in humans and show how current evidence strongly indicates that humans lack this trait." The paper states that "In summary, a thorough review of the literature shows that there is no scientific convincing evidence of the generation and incorporation of new neurons into the circuitry of the adult human brain, including the dentate gyrus of the hippocampus."  Noting how false claims persist within neuroscience, the paper states, "As Victor Hamburger, co-discoverer of the nerve growth factor, said at an informal meeting: 'A single report of an incorrect finding that many people like, takes more than hundreds of papers with negative findings to make an acceptable correction.' ” 
• A 2021 paper was entitled "Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus."

What the examples here mainly show is an example of the tendency of many neuroscientists to state as if they were facts extremely dubious claims. That goes on all over the place in the world of neuroscience. It occurs most commonly when neuroscientists make extremely dubious and unproven claims that memories are stored in the human brain, and that the human brain is the cause of human thinking, self-hood and imagination. 

Why Plasticity and Neurogenesis Fail to Explain Minds That Work Well After Massive Brain Tissue Loss

The web site The Conversation (www.theconversation.com) has a "Science and Technology" tab where we often are given very bad explanations for things. A particularly witless example was a recent article entitled "What really drives anti-abortion beliefs? Research suggests it’s a matter of sexual strategies." We were then given one of the many very silly work products of evolutionary psychology, something with a long history of providing groundless speculative explanations given a little scientific flavoring by some sprinkling of Darwinist verbiage. The speculation given (centered around the groundless idea that "sexually restricted people benefit from increasing the costs of sex") has no basis in either observation, logic or evolutionary theory. 

Another "bad explanation" article on The Conversation site attempts to address why people are skeptical of some claims of scientists. We read no mention of things such as the replication crisis, that an apparent majority of findings in scientific papers fail attempts to experimentally replicate them. Instead we read this:

"How can scientists increase their credibility? ... To increase trustworthiness, they can convey that their work is motivated by selfless goals."

This claim is very funny. Scientists work for salaries. The more papers they publish, and the more such papers are read and cited, the higher is the chance that a scientist will move up some career path that may lead from being a mere "reader" or adjunct professor or assistant professor to being a better-paid full professor with tenure. The ultimate career goal of a scientist is to become a famous professor, who makes lots of money by writing books that are widely read.  The work of scientists is not mainly motivated by selfless goals.

By contrast, consider a person such as myself. All of my blogs are free for anyone to read. I also have various books that you can access from my site www.markmahin.com or by using the link here. All of the books on those two pages can be read online for free. I have a Creative Commons license on all of my blogs, under which anyone can reproduce any of my posts for free, on any web site they have or any book they are publishing. I have never made a penny from my blogging or photographic activities, and a few occasional dollars I get from them is canceled out by my photographic expenses, which have been in excess of $2000. I take no contributions, and get no ad revenue. So when you read any of my posts, you can be sure that what I was writing or photographing was in no way motivated by money. 

Another "bad explanation" article on The Conversation website attempts to answer a different question. The article has this long title: "Game of Thrones star Emilia Clarke is missing ‘quite a bit’ of her brain. How can people survive and thrive after brain injury?"  We read that the talented actress Emilia Clarke had surgery removing significant portions of her brain, which occurred before she filmed most of the years of work she did on that show. 

This is not at all the most dramatic example of people functioning well despite major loss of brain tissue. Other more dramatic examples include:

(1) Many cases of epilepsy patients who were suffering from seizures so bad that they had half of their brains surgically removed, in an operation called a hemispherectomy.

(2) Some split-brain patients who had their epilepsy treated by severing the fibers (called the corpus callosum) that connects the two hemispheres of the brain.

(3) Many patients who lost the great majority of their brain tissue through diseases such as hydrocephalus, which slowly converts brain tissue to watery fluid. 

Contrary to claims that the mind is produced by the brain and that memories are stored in the brain, such massive loss of brain tissue often produces little change in memory or mental capacity.  My post "Preservation of Mind and Memories After Removal of Half a Brain" (which you can read here) describes cases in which removing half of a brain had no major effect on either mind or memory.  For example,  here is a quote from the  American Journal of Psychology, Vol. 46, No. 3 (Jul., 1934), pages 500-503, regarding work by a physician named Dandy:

"Dandy has completely removed the right cerebral hemisphere from eight patients....Later examinations showed no observable mental changes. The patients were perfectly oriented in respect of time, place, and person; their memory was unimpaired for immediate and remote events; conversation was always coherent; ability to read, write, compute, and learn new material was unaltered. Current events were followed with normal interest. There were no personality changes apparent; the patients were emotionally stable, without fears, delusions, hallucinations, expansive ideas or obsessions, and with a good sense of humor; they joked frequently. They showed a natural interest in their condition and future. They cooperated intelligently at all times throughout post-operative care and subsequent testing of function."

A 1966 paper was entitled “Long-term changes in intellect and behavior after hemispherectomy.” The paper refers to operations in which half of a brain is removed, often to stop very bad brain seizures. This paper gives very detailed “before and after” IQ score data on 11 people who had half of their brains removed. Eight of the 11 people had the left half of their brain removed, and the other three had the right half of their brain removed. Every single one of the 11 people was able to get an improved IQ score on at least one of the tests taken after half of their brain was removed, a score better than a corresponding score they had got before half of their brain was removed.  Patient 1 (a P.G.) had an IQ of 128 before half of his brain was removed. After half of his brain was removed, he scored 142 on an IQ test. 

This result should not come as any surprise to anyone familiar with the research of the physician John Lorber. Lorber studied many human patients with hydrocephalus, in which healthy brain tissue is gradually replaced by a watery fluid. Lorber's research is described in this interesting scientific paper. A mathematics student with an IQ of 130 and a verbal IQ of 140 was found to have “virtually no brain.” His vision was apparently perfect except for a refraction error, even though he had no visual cortex (the part of the brain involved in sight perception). In the paper we are told that of about 16 patients Lorber classified as having extreme hydrocephalus (with 90% of the area inside the cranium replaced with spinal fluid), half of them had an IQ of 100 or more.

The article in The Conversation does not mention such cases. But using the example of Emilia Clarke (who performed skillfully as an actress after apparently losing quite a bit of her brain because of brain surgery), the neuroscientist author of the article (Professor Anthony Hannan) offers two explanations for why minds would perform well after massive loss of brain tissue: "neural plasticity"  and neurogenesis. 

Let's look at whether either of these explanations is a strong one.

Poor Explanation #1: Neural Plasticity

To explain the phrase "neural plasticity" I should first start by explaining the simpler term "synaptic plasticity." The term "synaptic plasticity" has long been used by those who claim that memories are stored in synapses. It has often been claimed that when a memory is created, some synapses kind of mold themselves to store the memory. Those advancing this claim would sometimes claim that synapses are molded by experience or sensory experience rather as some clay can be molded by an artist.  

There has never been any robust evidence to support such claims. Instead of having evidence for memory formation by synaptic plasticity, we merely have evidence for constant remodeling and physical turnover in synapses. All synapses can be very roughly compared to the wet sand at the edge of the seashore, which is constantly remodeled by the action of the tides. What often goes on in neuroscience studies is that after some animal learns something, a neuroscientist will look at some synapses, and see some evidence of change. The neuroscientist will often claim that the change resulted from the learning that occurred. The fallacy in such work is that all synapses in the brain are constantly changing, regardless of whether anything is learned. So the mere observation of a change in some synapses does nothing to show that such change occurred because of something that an organism learned. 

The constant remodeling of synapses occurs largely because of the short lifetimes of synapse proteins. Synapses are made of proteins that have average lifetimes of two weeks or less. Such short lifetimes make an extremely strong reason for disbelieving claims that memories are stored in synapses. Human memories often last 1000 times longer than the average lifetime of synapse proteins. But despite the lack of good evidence for claims that memories are stored in  synapses, neuroscientists love to use the vague term "synaptic plasticity." The type of evidence cited for synaptic plasticity is usually just evidence for synaptic instability all over the brain. 

The term "neural plasticity" is a term similar to the term "synaptic plasticity." Neural plasticity is some alleged ability of the brain to rewire itself.  Connections between brain cells are constantly being built and broken down, just as vines between trees are constantly being built and decaying in the dense regions of the Amazon rain forest. 

However, there is no evidence that brains can rebuild themselves the way the liver can. A page at the NIH describes that ability of the liver:

"The liver has a unique capacity among organs to regenerate itself after damage. A liver can regrow to a normal size even after up to 90% of it has been removed."

But the brain has no such ability to regenerate itself. If you take out a part of the brain, it remains lost. When half of the brain is removed in a hemispherectomy operation to stop very bad seizures, the brain does not regenerate the missing half.  When a quarter or an eighth of the brain is removed to get rid of a cancerous tumor, the brain does not grow back the missing part. 

Professor Hannan makes this misleading claim: "The key to understanding how brains can recover from trauma is that they are fantastically plastic – meaning our body’s supercomputer can reshape and remodel itself." The brain is not a computer, and the brain lacks seven characteristics of information-storage devices such as computers, as I point out in my post "Seven Things in Fast Retrieval Systems, None of Which Your Brain Has." There is no evidence that brains reshape themselves or remodel themselves in any way that can explain the preservation of mental abilities after loss of large parts of the brain.  Evidence typically given for neural plasticity or synaptic plasticity should really be described instead as evidence for mental resiliency, the ability of the mind to keep functioning well despite brain damage.

Much of what Professor Hannan says to back up his claims are unproven and easy-to-discredit claims about brains storing memories. He provides no evidence at all that the brain generates very many more synapses or neurons to make up for synapses or neurons that were lost. About the best that he can do is to make this claim (which he does not support with specifics):

"With brain injury, the changes can be bigger; you get certain rewiring around the injury. These synapses can rearrange themselves to work around the damaged part."

Poor Explanation #2: Neurogenesis

The second thing  Professor Hannan attempts to do to explain well-functioning minds after massive brain damage is to appeal to what he calls neurogenesis: the ability of a brain to make new brain cells. He says this:

"But there’s another form of plasticity called neurogenesis. This involves little pockets in the brain where new neurons continue to be born throughout life. And there’s evidence that after brain injury these neural stem cells can be stimulated and migrate to the area of injury and make new neurons."

Unfortunately, the evidence for adult neurogenesis is very weak. Attempts to observe neurogenesis produce conflicting results. Many neuroscientists believe that human adults do not generate new brain cells in significant numbers. Even those who argue for neurogenesis claim numbers of new neurons through neurogenesis so low that they cannot appreciably explain the persistence of human mental abilities despite massive loss of brain tissue. 

A 2019 paper says this about adult neurogenesis (the formation of new neurons):

"Here we examine the evidence for adult human neurogenesis and note important limitations of the methodologies used to study it. A balanced review of the literature and evaluation of the data indicate that adult neurogenesis in human brain is improbable. In fact, in several high quality recent studies in adult human brain, unlike in adult brains of other species, neurogenesis was not detectable."

Below we see a recent paper with a title of "Mounting evidence suggests human adult neurogenesis is unlikely."

Even those who believe in adult neurogenesis claim that it produces a relatively small amount of neurons: only about one or two thousand per day. That is smaller than the number of brain cells that die each day. We don't know exactly how many brain cells die each day, but it has been estimated that adults lose roughly 10,000 brain cells per day. So neurogenesis is worthless for explaining minds that work well after massive brain tissue loss. Any gain produced by neurogenesis does not even make up for all the neurons being lost due to regular aging. 

In the poll here of 90+ neuroscientists, neuroscientists were asked whether they agreed with a series of statements. One of the statements was, "Damaged portions of the human brain regenerate and get well again." 88% of the neuroscientists disagreed with that statement. The story line of a self-healing brain that Hannon is insinuating does not match the opinions of the vast majority of neuroscientists. Also 56% of the neuroscientists agreed with the statement, "The human brain stops growing at the end of adolescence," just as if they did not believe in substantial adult neurogenesis. 

Nothing that Hannan mentions has any value in explaining the preservation of old memories and old learning despite massive loss of brain tissue. If you still remember something you should have forgot after losing half your brain, that cannot be explained through any explanation such as growing new synapses or new neurons. Such new synapses or new neurons would not have the information allegedly stored in the old synapses and neurons that had been surgically removed. 

So neuroscientists such as Hannan have no credible explanation to offer as to why human minds should continue to perform so well after massive loss of brain tissue. There is only one credible way to explain this paradox: by postulating that the brain does not produce the mind, and that the brain is not the storage place of memories.