Here is the latest in a series of videos I am making.
Monday, April 8, 2024
Wednesday, April 3, 2024
The Guardian's Misleading Story on Near-Death Experiences
The British paper the Guardian recently gave us a junk story on the topic of near-death experiences. It pushed a groundless narrative that a neuroscientist named Jimo Borjigin has done something to help explain such experiences, which is not at all correct. Borjigin's work on this topic started out with her 2013 paper with the misleading title "Surge of neurophysiological coherence and connectivity in the dying brain." The paper makes a misleading use of the technical EEG terms "coherence" and "connectivity."
Nothing impressive is seen. It's just what you would expect: brain signals trailing off and dying out very quickly after the heart stops. This data offers no justification for a title of "Surge of neurophysiological coherence and connectivity in the dying brain." An honest title of the paper would have been: "Brain waves very quickly trail off and die out after hearts stop in rats."
- "Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain." Here we have another misleading use of the word "surge" in a science paper headline, a paper co-authored by one of the researchers who authored the equally mistitled rat study "Surge of neurophysiological coherence and connectivity in the dying brain." The paper merely describes a little brain activity in two people after a respirator was turned off, with no evidence of brain activity continuing for more than a few seconds after the heart has stopped. The lines on brain waves charts go up and down, and there are seven or so channels of brain waves (including a gamma channel); so at any second you can usually find some little line going up and call that a "surge," although at the same time other lines (representing other brain wave channels) will probably be going down. Using the term "surge" in the title of the paper was misleading, rather like tracking the price of Microsoft, seeing it go up 2% at 2:00, and calling that a surge. The authors of the study did not even report a surge in gamma waves, one of the brain wave channels. Eager to get something they could call a surge, the authors got their little "surge" after some statistical fiddling with the signals, to get some statistical measure that only shows up after arbitrary analytics. Almost any random ten seconds of brain wave activity can be statistically analyzed to show a little "surge" somewhere, if you're willing to dredge up secondary statistical measures. Keep torturing the data, and it will confess as you wish. Shamefully, the journal Science has an article on this paper with the misleading headline "Burst of brain activity during dying could explain life passing before your eyes"; and the Smithsonian site has an equally misleading click-bait headline of "Surging Brain Activity in Dying People May Be a Sign of Near-Death Experiences." There is no evidence that either of these two people had an experience of "life passing before their eyes" or anything like near-death experiences. The subjects were unconscious when the respirator was turned off, and there is no evidence of any consciousness. Unconscious people have gamma wave activity (the activity reported), and you have plenty of gamma activity while you are sleeping. No "neural correlates of the NDE" were reported by the paper. As two MDs point out in a commentary on this paper, "The researchers reported no evidence whatsoever that these brain activities were correlated with conscious experiences in those two patients—and no reason to compare these results with prospective NDE studies in patients who have survived a cardiac arrest."
The term "isoelectric" or iso-electric in reference to brain waves means a flat-lining equivalent to no electrical activity in the brain, as measured by EEG readings. The paper here states, "Within 10 to 40 seconds after circulatory arrest the EEG becomes iso-electric." Figure 1 of the paper here says that such an isoelectric flat-lining occurred within 26 seconds after the start of ventricular fibrillation, the "V-fib" that is a common cause of sudden cardiac death, with "cortical activity absent." Also referring to a flat-lining of brain waves meaning a stopping of brain electrical activity, another scientific paper says, "several studies have shown that EEG becomes isoelectric within 15 s [seconds] after ischemia [heart stopping] without a significant decrease in ATP level (Naritomi et al., 1988; Alger et al., 1989)." Another paper tells us this about brain waves and infarction (obstruction of blood flow), using CBF to mean cerebral blood flow, and the phrase "the EEG becomes isoelectric" to mean a flat-lining of brain electrical signals:
"When normal CBF declines, the EEG first loses the higher frequencies (alpha and beta bands), while the lower frequencies (delta and theta bands) gradually increase. When the CBF decreases further towards an infarction threshold, the EEG becomes isoelectric."
Similarly, another paper refers to blood pressure, and tells us, "When flow is below 20 mL/100 g/min (60% below normal), EEG becomes isoelectric." meaning that brain electrical activity flat-lines. The 85-page "Cerebral Protection" document here states, "During cardiac arrest, the EEG becomes isoelectric within 20-30 sec and this persists for several minutes after resuscitation." Another scientific paper states this:
"Of importance, during cardiac arrest, chest compliance is not confounded by muscle activity. The EEG becomes isoelectric within 15 to 20 seconds, and the patient becomes flaccid (Clark, 1992; Bang, 2003)."
You can find quite a few additional papers asserting that brains flat-line very quickly after cardiac arrest by doing Google or Google Scholar searches for the phrase "EEG becomes isoelectric" or "EEG becomes iso-electric."
Postscript: A recent scientific paper referring to EEG readings of brain waves states this:
"The trajectory of EEG activity following cardiac arrest is both well defined and simple. It consists of an almost immediate decline in EEG power, which culminates in a state of isoelectricity [flatlining] within 20 s [seconds]."
The paper refers to three studies "where gamma oscillations are essentially or mostly artifactual and non-functional biorhythms masquerading as authentic EEG signals," noting how such oscillations can be produced by muscle movements. The paper concludes by saying this about Borjigin's blips: "Regardless of what the electrogenesis of the gamma spikes ultimately turns out to be, it is highly unlikely that they could be responsible for generating an NDE [near-death experience]."
Wednesday, March 27, 2024
Traumatic Brain Injury Results Clashing With Prevailing Dogmas About Brains
I have at this site written quite a bit about the preservation of mind and memory after surgeries that removed large portions of the brain, sometimes half of the brain. Examples were my posts "Preservation of Mind and Memories After Removal of Half a Brain" and "Cases of High Mental Function Despite Large Brain Damage." There is another way to look for evidence of how sensitive the mind is to brain damage: we can look for cases of cognitive effects of traumatic brain injury (often referred to as TBI). Every year we have many cases of traumatic brain injury or TBI that result from events such as accidental falls, traffic accidents, car crashes or people being shot in the head.
Before discussing such cases, I will need to discuss how there are several reasons why we should assume that the cognitive effects of traumatic brain injuries are probably not as high as typically reported in scientific studies.
Confounding factor #1: the incentive of many to perform poorly on cognitive tests after a brain injury. There is strong reason to suspect that in many cases people given cognitive tests after a traumatic brain injury may not be trying as hard as they can on the tests. Some of the subjects (such as those injured in a car accident either inside or outside of a vehicle or those who fell in a work accident) may have pending law suits or pending benefit applications, and may think that good performance in cognitive tests may reduce their chance of being rewarded lots of money in a law suit or through a benefit application. There are three ways in which a person might receive money after a traumatic brain injury:
(1) The person might engage in a law suit against a car driver that results in a large settlement such as an award of $100,000 or more.
(2) A person might apply for benefits under the Worker's Compensation program that provides monthly payments to workers injured on the job.
(3) A person might apply for disability benefits that can be provided by the Social Security Administration if a worker has been judged to be disabled.
Given all of these possibilities for potential financial gain after having a traumatic brain injury, it would not be surprising if many people who have had traumatic brain injury do not try as hard as they can on tests of their cognitive abilities. Many people who have traumatic brain injury may think that getting a high score on a cognitive test might damage their ability to get future benefits or future settlement money.
Indeed, in the paper "Noncredible Explanations of Noncredible Performance on Symptom Validity Tests" we read quite a bit about reasons for thinking that some of those tested after traumatic brain injury might not have been trying as hard as they could. Here are some excerpts:
"Invalid test results from poor effort or deliberate underachievement do not occur only in groups where there is an obvious external incentive to appear cognitively impaired, such as those seeking financial compensation for cognitive impairment. Even in groups previously assumed to be highly motivated to do well, effort may be poor, leading to invalid test results....Neuropsychologists now know that, in many different contexts, effort can be low to a degree that is sufficient to invalidate test results, especially if there is an incentive to appear impaired (e.g., Chafetz, 2008; Chafetz, Prentkowski, & Rao, 2011; Flaro, Green, & Robertson, 2007; Sullivan, May, & Galbally, 2007)....For people with an incentive to appear impaired and who fail effort tests, the observed test scores typically underestimate actual ability to a marked degree (Fox, 2011; Green, 2007; Meyers et al., 2011; Stevens et al., 2008). In groups of disability claimants or compensation claimants, including those who were already receiving financial disability benefits, it was found that about 30% of cases were not making enough effort to produce valid test results, and in the MTBI group, the figure was roughly 40% (Green et al., 2001)."
There are techniques that can be used to help weed out "memory malingering" in memory tests of those with traumatic brain injury. One technique is to include some easy tests that almost no one fails, and look for failure in such tests, which might be an indication of lack of effort. Another technique is to take the same tests at different intervals, taking the best result at any interval as being the more reliable indication of memory performance.
Confounding factor #2: selection bias in picking subjects having traumatic brain injury. We must wonder whether the scientists selecting the subjects for papers on traumatic brain injury have a bias in looking for subjects with particularly bad memory problems, because they are hoping to get a result that fits in with the expectations of their colleagues and peer reviewers of their papers. We should look for any confession by the paper authors that they selected patients who had reported memory problems, rather than selecting random patients with traumatic brain injury, regardless of how good their memory was. Any such confession means that the paper may not be telling us about what percentage of traumatic brain injury patients suffer from similar problems. Similarly, if scientists select for some study only people who are gay alcoholics, they may report a high alcoholism rate among gay people; but we won't learn from such a method what percentage of gay people are alcoholic.
Confounding factor #3: the group of those with traumatic brain injury may be less intelligent and more forgetful than an average group of non-injured people of the same size. While traumatic brain injury often occurs for reasons beyond any person's control, very often such injury happen because of some causal factor that might have been avoided by someone of excellent intelligence and memory. For example, many traumatic brain injury cases occur to reckless or intoxicated drivers, to people who failed to use seat belts, or people who were walking in some dangerous way, to people who were not wearing helmets while bicycling or riding motorcycles, to people who recklessly jaywalked, and so forth. We therefore have a strong reason to suspect that the group of all people with traumatic brain injuries may have had a below-average intelligence or a below-average memory, or both. Accordingly, showing a small difference in memory or intelligence between those with traumatic brain injury and those without injury does not necessarily show that brains make minds or that brains store memories.
Confounding factor #4: traumatic brain injury may degrade perception, muscle skills, eyesight and hearing skills without decreasing core intelligence and memory, in a way that causes lower scores on cognitive tests. Cognitive tests are rarely pure measures of memory and intelligence. For example, a person with a damaged brain may have a damaged vision ability that degrades his performance on paper-based cognitive tests. Also, a person with a damaged brain may have a damaged muscular ability that degrades his performance on any test requiring muscle skills such as filling in the right little circles on a test sheet.
Confounding factor #5: incidents producing traumatic brain injury may increase apathy, depression or pain, resulting in lower scores on memory tests that are not caused by lower cognitive ability. It is has often been reported that following a traumatic brain injury someone may experience pain, depression or an increased level of apathy. Such factors might tend to cause a person to perform more poorly on cognitive tests, for reasons other than cognitive deficits.
Confounding factor #6: memory tests often involve subjective scores by analysts who may be biased towards giving negative scores to those with traumatic brain injury. Some memory tests can be performed without any subjective analysis by an analyst. For example, with the Famous Faces Test, a person either does or does not name the person shown in a photograph. But in other widely used memory tests, there is a strong possibility of biased analysis. For example, there is an Autobiographical Memory Interview test in which an analyst rates how well a subject has performed when asked to recall incidents at various parts of his life. But if an analyst knows that a subject has had traumatic brain injury, the analyst may be more prone to rate the subject's response poorly. To avoid such a bias, a robust blinding protocol would be needed, so that the analyst cannot tell whether the subject had a brain injury. But neuroscience experiments typically fail to use blinding protocols, and when they are used they are typically not robust protocols. A robust blinding protocol for a memory test would be one in which analysts could not even see the people giving answers, as such people would often have physical signs of their injury.
In light of these six confounding factors, under the hypothesis that the brain does not make the mind and does not store memories, we might still expect to see some modest differences in cognitive test scores between those with traumatic brain injuries and those without such differences. But we should expect that the differences will usually not be terribly dramatic, and that differences might tend to show up sometimes and be absent in other cases. Let us look at some scientific papers to see whether such an expectation is met.
- The paper "Cognitive Impairment 3 Months After Moderate and Severe Traumatic Brain Injury: A Prospective Follow-Up Study" gives us the result of cognitive tests on people who had brain injuries as the result of events such as falls and traffic accidents. In the Discussion section we read that after moderate Traumatic Brain Injury (TBI), "most patients had a normal neuropsychological assessment," with no more than 1 score much below normal (or, to put it more technically, no more than 1 score below 1.5 standard deviations below the norm). We read that "even after severe [brain] injury, normal performances were found in one third of patients." The authors say, "This was unexpected." We are told that the average total IQ score of 35 subjects with moderate traumatic brain injury was an above-average score of 109, and the average total IQ score of 26 subjects with severe traumatic brain injury was an above-average score of 103.
- The paper "Neuropsychological functioning during the yearfollowing severe traumatic brain injury" studied cognitive functioning in 65 subjects who had severe brain damage, mostly after road traffic crashes. The patients were rated with a level of impairment of "mild" or "severe" on various measures, based on tests 6 months after the injury and 1 year after. Fewer than half of the subjects were rated as having "severe" impairment in memory performance tests taken at the 1-year mark. Only 9% of the subjects were rated as having "severe" impairment in one test of executive function at the 1-year mark, with a minority rated as having "severe" impairment in another test executive function at the 1-year mark. One test of attention at the 1-year mark result showed only 8% with a severe impairment, and another test of attention at the 1-year mark result showed only 28% with a severe impairment. The average IQ of the brain-damaged subjects was 93, and we don't know whether this below-average result was caused by brain injury. There is reason to suspect that the set of average people suffering from traffic accident brain damage may be slightly below average in IQ, given that those with higher IQ might tend to avoid such accidents.
- The paper "Association of Traumatic Brain Injury With Dementia and Memory Decline in Older Adults in the United States" used a very large sample of 9,794 patients who had an assessment of traumatic brain injury. The study says, "There was no significant relation between history of TBI [traumatic brain injury] with LOC [loss of consciousness] and memory score or memory decline." We read this: "In a nationally representative prospective cohort of older adults free of dementia at baseline, we did not find evidence for any long-term associations between history of TBI [traumatic brain injury] with LOC [loss of consciousness] (of unknown frequency and severity) and risk of dementia over 14 years of follow-up. " We read that "similarly, decline in memory performance did not differ between participants with or without history of TBI with LOC." The authors state, "Our findings showing no association between TBI history with LOC and dementia are consistent with the results of several other recent studies looking at dementia, AD [Alzheimer's Disease], or AD biomarkers or neuropathology."
- The paper "Working memory after severe traumatic brain injury" tested 30 subjects who had almost all suffered brain damage due to high-velocity motor vehicle accidents. All of the patients had a post-traumatic amnesia (typically an inability to remember what happened a certain number of days before the accident). We are told that this post-traumatic amnesia lasted for at least seven days in all patients, and thar for 14 of 21 patients the post-traumatic amnesia lasted 30 days or more, "suggesting that the majority of patients sustained an extremely severe TBI [traumatic brain injury]." The paper has nice easy-to-read graphs comparing the difference in performance between these brain-injured patients and control subjects. For a "digit span" working memory test (Figure 1) and a "word span" working memory test (Figure 3), we see no major difference between the brain-damaged patients and control subjects. There is also no difference in a "Brown-Peterson task" test, when conducted with "no interference." On some other tasks there is a substantial difference.
- The paper "Working Memory after Traumatic BrainInjury in Children" tested working memory in eighty children with mild or severe traumatic brain injury (TBI). The paper has nice easy-to-read graphs comparing the performance of the brain-injured with controls, and the first two of the graphs show no appreciable difference in performance in two working memory tests, even when comparing the severe cases with control (uninjured cases).
- The paper "Central executive system impairment in traumatic brain injury" is one that does not give us a random sample of patients with traumatic brain injury, because the paper tells us this about its 64 patients: "Patients were selected for participating in the study if they complained of lack of attention, poormemory or loss of efficiency in everyday life." Despite such a selection bias, Table III of the paper tells us that the majority of the subjects had "normal performance" in long-term memory acquisition, long-term memory storage, long-term memory delayed recall, sustained attention and short-term memory, with an average of about 60% of the subjects being normal in such areas.
- The paper "Models of Exceptional Adaptation inRecovery After Traumatic Brain Injury: A Case Series" discusses nine cases of people who suffered severe brain injuries causing them to be in comas of between 2 and 17 days. All of them made remarkable recoveries. For example, a computer engineer suffering a 15 day coma after a severe crash injury went back to his high-tech job and "helped to plan a complete reorganization of his division." Another recovered from a 14-day coma after a high-speed crash, earning a 4.0 grade point average.
- The paper "Working memory outcomes following traumaticbrain injury in children: A systematic review withmeta-analysis" presents no new experiments, but reviews existing papers on the topic. Using the acronym CE to mean "central executive," the paper says, "Further analyses revealed significant, moderate effect sizes for studies that utilized verbal CE tasks (k = 19, d = −0.56, 95% CI −0.71, −0.41, p < .001), but non-significant and small effect sizes for studies that utilized visuo-spatial CE tasks (k = 7, d = −0.26, 95% CI −0.60, 0.08, p = .13)." The paper notes that "Several studies, however, did not find deficits in CE [executive functions] in children and adolescents who had sustained TBI [traumatic brain injury]." The paper says, "The results of our meta-analysis, however, indicate that children with TBI do exhibit deficits, albeit small-to-moderate ones, in the PL[phonological loop] relative to controls, but not in the VSSP [visual-spatial sketchpad]." We read that "no relation was found between TBI severity and the two storage components," and that "In contrast to findings relating to the impact of TBI severity and to our expectations based on literature suggesting that the frontal lobes play a critical role in WM [working memory], no relationship was found between frontal injuries and WM [working memory] outcomes."
Wednesday, March 20, 2024
She Has Photographic Memory and Severe Unmanageable Epilepsy
The normal facts of human memory performance are sufficient to discredit claims that memory formation and memory recall are brain activities. There is not a neuroscientist who can credibly explain how a brain can store a detailed memory. Nothing known to neuroscientists can explain how learned information or experiences could be translated into brain states or synapse states. Neuroscientists claim that memories are stored in synapses, but we know that the proteins in synapses have average lifetimes of only a few weeks, 1000 times shorter than the maximum length of time that humans can remember things (more than 50 years). We know the kind of things (in products that humans manufacture) that make possible an instant retrieval of stored information: things such as sorting, addressing, indexing, and read/write heads. The human brain has no such things. Humans such as actors playing the role of Hamlet can recall large bodies of text with 100% accuracy, but such recall should be impossible using a brain in which each chemical synapses only transmits a signal with 50% accuracy or less. Brains are too slow, too noisy and too unstable to be the source of human memory recall which can occur at blazing fast speeds with 100% accuracy.
Page 158 of the document here quotes a 19th century newspaper report told of a young girl (Ethel Carroll) with such exceptional memory for speech and music that it was like photographic memory :
"The first time that the child showed her phenomenal gift was at the age of eleven months. At that time she was taken to see one of Hoyt's plays at the Macdonough Theatre. Upon returning to her home she surprised every one by repeating, word for word, one of the popular songs. From that time until now little Ethel has been a regular playgoer. Now, at the age of four, her memory has developed so remarkably that it is a common thing for her after seeing a new play to sing, without a mistake or the least sign of hesitation, song after song that she had never heard before. She can also repeat the lines of the play with wonderful correctness. The child has a retentive memory for names and dates. In spite of the fact that large numbers of people see her daily, drawn by curiosity, she never forgets the name of any one who is introduced to her, and can tell even the exact day when she first met them, though it may be months after. Recently her wonderful memory was put to a severe test at a concert recital in Oakland. After the performance she was asked if she remembered a certain recitation on the programme, remarkable alike for its length and peculiar phrasing. She had never heard it before, but with a confident smile and a certain enchanting carelessness of manner she recited the entire piece without a break."
Wednesday, March 13, 2024
A Biologist Calls "Orthodox Science" a "Religion" and "Belief System"
A recent Substack post by cell/molecular biologist Mike Klymkowsky is entitled "Orthodox Science as a (mostly good) religion." He states this:
"As it turns out, I found myself moving to another religion - science, particularly the scientific tradition that emerged in Europe, a tradition open to, and built upon the contributions of many peoples around the globe. The orthodox scientific gospel has been widely embraced and has served as the driver of technological advancement, including dramatic effects on many aspects of human well-being. 'Orthodox Science' embraces a belief system based on the assumption that we can understand the universe exclusively in naturalistic terms, there is no magic, no supernatural forces involved."
What Klymkowsky has called "Orthodox Science" is better described as Darwinist materialism. It is a creed that is very popular among scientists (particularly biologists), but the creed is not actually science in the sense of facts established by observation. The creed of Darwinist materialism can be stated like this:
- "Earthly biology can be explained entirely by naturalistic explanations such as natural selection and random mutations."
- "The human mind can be explained entirely by brain activity."
- "Charles Darwin provided some brilliant insight that eliminated the need to postulate any design or purpose in nature."
- "Life appeared on our planet purely because of lucky random combinations of chemicals."
- "Everything is pretty-well explained by science professors who assume there is just matter and energy; so there's no need to believe in anything like souls, spirits, or the paranormal."
Here is another rather similar definition: we can define a religion as a set of beliefs about the fundamental nature of reality and life, or a recommended way of living, typically stemming from the teachings of an authority, along with norms, ethics, rituals, roles or social organizations that may arise from such beliefs. This definition covers Christianity, Islam, Taoism, Confucianism, Buddhism, and Scientology, religions which stem from authority figures such as Jesus, Muhammad, Moses, the writers of the Bible, Lao-Tzu, Gautama Buddha, Confucius, and L. Ron Hubbard. Interestingly, using the same definition of religion, it seems we should also classify Darwinist materialism as a religion. It is a fundamental way of looking at the nature of life, stemming from the teachings of an authority figure (Charles Darwin).