Sunday, October 30, 2022

Misleading Claims in Attempts to Naturally Explain Near-Death Experiences and Out-of-Body Experiences

Near-Death Experiences and Out-of-Body Experiences:  Phenomena Defying "Brains Make Minds" Claims

The dogma that our minds are produced by our brains is a dogma that makes some very definite predictions. One prediction of such a dogma is that human mental activity should completely stop both after someone dies and after someone's brain shuts down. During cardiac arrest, a person will “flatline.” Not only will his heart stop beating, but his brain waves will also stop within 2 to 20 seconds after his heart stops. This means the brain has stopped working. Unless the person is revived through medical resuscitation efforts, he will die.

But contrary to the predictions of the dogma that minds are produced by brains, it is often found that mental activity continues after both the heart and the brain have shut down. Such events are called near-death experiences.

Near-death experiences first came to widespread public consideration in the 1970's with the publication of Raymond Moody's 1975 book Life After Life. Patching together elements from different accounts, Moody described an archetypal typical near-death experience, while noting that most accounts include only some elements in the described archetype. The archetype NDE included elements such as a sensation of floating out of the body, feelings of peace and joy, a life-review that occurs very quickly or in some altered type of time, a passage through a tunnel, an encounter with a being of light, and seeing deceased relatives. Accounts of near-death experiences and out-of-body experiences actually appeared before Moody's book, as you can read about hereThe pages here and here describe out-of-body experiences of the nineteenth century. The page here lists a nineteenth century near-death experience involving the "life review" so often reported in near-death experiences. The page here (from a 1972 book) mentions four cases of someone being told that he or she must "go back" during an out-of-body experience, a common element in near-death experiences. 

study on near-death experiences was published in the British medical journal The Lancet in 2001. The study interviewed 344 patients who had a close encounter with death, generally through cardiac arrest. 62 of those reported some kind of near-death experience. 15 reported an out-of-body experience, 19 reported moving through a tunnel, 18 reported observation of a celestial landscape, 20 reported meeting with deceased persons, and 35 reported positive emotions.

The AWARE study was published in 2014 in the journal Resuscitation. It was entitled, “AWARE—AWAreness during REsuscitation—A prospective study.” The URL can be found here.

The AWARE study name is an acronym for awareness during resuscitation – the type of resuscitation that takes place when a person has a heart attack (cardiac arrest) and almost dies. The study collected data at 15 different hospitals, and was carried on over the course of four years. The study attempted to gather accounts of people's recollections in hospitals after they had very close encounters with death, typically during a heart attack or cardiac arrest. Over 2000 cardiac arrest cases were studied, and there were only 330 who survived to leave the hospital. Of those 330, only 101 met eligibility requirements, agreed to be interviewed, and also agreed to “stage 2” interviews.

So the study ended up with a group of only 101 persons who had experienced a close encounter with death, generally because of a cardiac arrest. Of this pool of 101 persons, 22% answered “Yes” to the question, “Did you have a feeling of peace or pleasantness?” 13% answered “Yes” to the question, “Did you feel separated from your body?” 13% answered “Yes” to the question, “Were your senses more vivid than usual?” 8% answered “Yes” to the question, “Did you seem to encounter a mystical being or presence, or hear an unidentifiable voice?” 7% answered “Yes” to the question, “Did you seem to enter some other, unearthly world?” Only 3% answered “Yes” to the question, “Did you see deceased or religious spirits?”

These results are corroboration of published accounts of what typically happens in a near-death experience, although the numbers are smaller than those reported in the Lancet study. As discussed here, the AWARE study does quote one respondent who gives an account very much like what has been published in previous books on near-death experiences:


"I have comeback from the other side of life. ..God sent (me) back,it was not (my) time — (I) had many things to do. ..(I traveled) through a tunnel toward a very strong light, which didn’t dazzle or hurt (my) eyes. ..there were other people in the tunnel whom (I) did not recognize. When (I) emerged (I) described a very beautiful crystal city. .. there was a river that ran through the middle of the city (with) the most crystal clear waters. There were many people, without faces, who were washing in the waters. ..the people were very beautiful. .. there was the most beautiful singing. ..(and I was) moved to tears. (My) next recollection was looking up at a doctor doing chest compressions."

While the AWARE study did not find a very large number of cases of near-death experiences, the study did seem to “hit the jackpot” in regard to one case of a 57-year-old patient who said that he floated out of his body while being revived from his cardiac arrest. The man said that a woman appeared in a high corner of the room, beckoning him to come up to her. He said that despite thinking that was impossible, he found himself up in the high corner of the room, looking down on the medical team trying to revive him. The man described specific details of the revival efforts, including the presence of a bald fat man with a blue hat, a nurse saying, “Dial 444 cardiac arrest,” his blood pressure being taken, a nurse pumping on his chest, a doctor sticking something down his throat, and blood gases and blood sugar levels being taken.

Here is what the AWARE scientific paper said in regard to the accuracy of these recollections:


"He accurately described people, sounds, and activities from his resuscitation...His medical records corroborated his accounts and specifically supported his descriptions and the use of an automated external defibrillator (AED). Based on current AED algorithms, this likely corresponded with up to 3 minutes of conscious awareness during CA [cardiac arrest] and CPR."

So here is a man who had a heart attack, and should have been unconscious during the medical efforts to revive him. Instead he accurately describes the details of what happened. Moreover, he claims that he observed these details while in a position above his body, in the high corner of the medical room. What we have here is what seems like a good-as-gold vintage “out of the body experience,” one with details that have been verified. This is an example of what is called a veridical near-death experience – one with observations that were subsequently verified.

In terms of its credibility and evidence value, the case may rival the famous Pam Reynolds case. At the time of her brain operation, the late Pam Reynolds was a 35-year old who had a large brain aneurysm. She underwent a very complicated operation that involved pumping out her blood and chilling her body temperature to only 60 degrees. Some twenty medical personnel worked on the complex operation.

After the successful operation was over, Reynolds reported having a near-death experience during the operation. She reported floating out of her body, and witnessing her operation. She accurately reported details of some medical equipment that was used to cut her skull open, describing it as a “saw thing...like an electric toothbrush,” with “interchangeable blades” that were stored in “what looked like a socket wrench case.” She reported someone complaining that her veins and arteries were too small. These details were later verified. This was despite the fact that during the operation Reynolds eyes were covered throughout the operation, and her ears were plugged with earplugs delivering noise of 40 decibels and 90 decibels (not to mention that her body was chilled to a level at which consciousness should have been impossible).

Reynolds said that she then encountered a tunnel vortex, saw an incredibly bright light, heard her deceased grandmother calling her, and encountered several of her deceased relatives. Reynolds says she was told by her uncle to go back through the tunnel, and to return to her body. These details were originally reported in the 1998 book Light and Death by Michael Sabom MD. That book includes diagrams of the medical equipment used to cut open Reynold's skull. They match her descriptions very well.

Many people have heard of one or two of these veridical near-death experiences, perhaps the Pam Reynolds case or the often-told story about “Maria's shoe.” But judging from the book The Self Does Not Die: Verified Paranormal Phenomena from Near-Death Experiences, these veridical near-death experiences may not be so rare. That book describes many cases similar to that of the Pam Reynolds case. My post here gives a summary of the main cases that book discusses. That post discusses many cases in which people correctly observed things during near-death experiences that should have been quite impossible for them to have observed, given their location and medical condition. 

A phenomenon that overlaps with near-death experiences is out-of-body experiences, in which a person reports either leaving his body and going far away from it, or viewing his body while not in his body.  The diagram below roughly shows the relation between near-death experiences and out-of-body experiences. A person can have an out-of-body experience without being close to death. The fraction depicted below (about 25%) roughly corresponds to data from the AWARE study, in which there were  55 subjects reporting awareness during a cardiac-related near-death experience, and 13 of them answered "Yes" to the question "Did you feel separated from your body?"

out-of-body experiences

The diagram above merely shows a rough estimate of the percentage of people having near-death experiences who report out-of-body experiences. The question of what such a percentage may be is clouded by the fact that those having near-death experiences may report being in a kind of different body from their earthly body. In the paper The Phenomenology of Near-Death Experiences by Bruce Greyson and Ian Stevenson, which examined in depth 78 near-death experiences, we have this very interesting quote: 

"The impression of having some sort of nonphysical body separate from the physical body was reported by 58% of our respondents (77% of those reporting out-of-the-body experiences)." 

Pages 34-38 of the book Out of Body Experiences; A Handbook describes how out-of-body experiences have been reported for centuries in cultures all over the world. We read, "In 1978 a cross-cultural study by Shiels revealed that only three of 44 societies did not hold a belief in OBEs." There is a large body of literature involving people who claimed to have had out-of-body experiences. Many accounts can be found in the various editions of the Journal and Proceedings of the British Society for Psychical Research and the American Society for Psychical Research (including the account described here). A long account of out-of-body experiences was given in the 1929 book The Projection of the Astral Body by Sylvan J. Muldoon, which you can read hereIn the 1960's and 1970's the scholar Robert Crookall PhD collected many accounts of out-of-body experiences.  His works on the topic include these:

  • The Supreme Adventure (1961), which you can read here
  • The Techniques of Astral Projection (1964), which you can read here.
  • More Astral Projections (1964), which you can read here
  • Out-of-the-Body Experiences (1970), which you can read here.

The More Astral Projections book gives about 160 cases of out-of-body experiences. In the accounts collected by Crookall, a large fraction or most of those reporting out-of-body experiences reported being in a kind of second body (what can be called a soul-body), with such a thing often mysteriously connected to the physical body by a kind of kind of link or cord, one often described as elastic.  

A very important point to remember is that in general neuroscientists are almost never serious scholars of paranormal phenomena. So if you ever hear a neuroscientist make generalizations about near-death experiences or out-of-body experiences, with very high likelihood you will be hearing someone talking about a topic he has not seriously studied.

Misleading Claims in Attempts to Neurally Explain Near-Death Experiences

There are two ways in which materialists attempt to deal with reports of paranormal phenomena:
(1) They may pretty much ignore the phenomena, say little or nothing about it, and hope that the public pays no attention to it.
(2) They may attempt to offer some evidence that they think may help to explain away the phenomena. 

Materialists have figured out that method (1) above does not work for near-death experiences, because near-death experiences are too well known. So they have made some attempt along the lines of method (2) above. There is a tiny mini-body or micro-body of papers and articles attempting to offer evidence for a neural explanation or some kind of neural account for near-death experiences. A typical feature of such papers and articles in dishonesty and distortion. 

Let's look at some of the papers most commonly cited in articles attempting to make it sound like there is some neural account to be told clarifying near-death experiences. Most of these articles cite a 2013 paper with the very misleading title "Surge of neurophysiological coherence and connectivity in the dying brain." The paper makes a misleading use of the technical EEG terms "coherence" and "connectivity."

An EEG is a device for measuring brain waves, one requiring the attachment of multiple electrodes on the head. In the technical jargon of EEG analysts, "coherence" means some length of time in which you are getting the same type of brain waves from two different regions of the brain. The paper here states, "Coherence is one mathematical method that can be used to determine if two or more sensors, or brain regions, have similar neuronal oscillatory activity with each other. There are different ways in which the term "connectivity" is used by neuroscientists. One of these ways is "structural connectivity" meaning the number of connections between brain cells. But, according to that paper, there's another way in which "connectivity" is used: "Functional connectivity identifies activity brain regions that have similar frequency, phase and/or amplitude of correlated activity." 

So given such speech customs, a neuroscientist analyzing the ups and downs of brain waves can claim "coherence" or "connectivity" as long as he sees any type of similarity between different regions of a brain giving the same kind of EEG readings. This is what the authors of the 2013 paper did.  What they observed was simply the brain waves of rats quickly dying off to become a flat line. But because the brain waves from each regions quickly trailed off and died off in the same way, the authors have called this behavior "coherence" and "connectivity." 

While this may not be a very clear case of an outright lie (given the speech habits of EEG analysts), the title of the paper is misleading, because it creates a very false impression in the minds of 95% of the people who read it. 95% of the people reading a title of "Surge of neurophysiological coherence and connectivity in the dying brain" will think that some indication was found of increased cognitive activity in dying brains. The paper found no such thing.  The "coherence" and "connectivity" supposedly found was not a surge but merely a blip, and it did not involve anything like some surge of mental activity. Nothing whatsoever was found that can help to neurally explain near-death experiences. In fact, there is every reason to think that the at time when this little blip of claimed "coherence" and "connectivity" occurred, all of the rats were unconscious. 

Figure 1 of the paper is shown below. We see EEG brain wave signals from rats who were injected with a chemical causing the heart to stop. 


Nothing impressive is seen. It's just what you would expect: brain signals trailing off and dying out very quickly after the heart stops. This data offers no justification for a title of "Surge of neurophysiological coherence and connectivity in the dying brain." An honest title of the paper would have been:  "Brain waves very quickly trail off and die out after hearts stop in rats." 

After this paper with a misleading title was published, we had innumerable misleading citations of it in the articles of materialist or mainstream writers, claiming or insinuating that the paper showed or suggested something it did not either show or suggest. An example was a National Geographic article with the misleading title "In Dying Brains, Signs of Heightened Consciousness." The 2013 "Surge of neurophysiological coherence and connectivity in the dying brain" paper had not anything whatsoever to show "signs of heightened consciousness" in the dying rats it studied. Similarly, a 2017 Big Think article linked to the 2013 paper and claimed, "One 2013 study, which examined electrical signals inside the heads of rats, found that the rodents entered a hyper-alert state just before death." This claim is totally false, and the paper suggested nothing of the sort.  

These days this kind of thing goes on constantly in the world of science journalism and materialist apologetics:
(1) Scientists often give their papers titles that are not justified by anything they observed (partially to maximize their chance of getting the paper citations that scientists crave).
(2) Journalists adding an additional layer of hype, distortion and misrepresentation, by claiming the papers showed or suggested something that the papers did not provide any good evidence for.  It's a "give 'em an inch, and they'll take a mile" kind of situation. For example, if a scientific paper mildly suggests that just maybe some odd observations could have been produced by extraterrestrials, the paper will be mentioned in dozens of new stories breathlessly claiming that scientists have shown extraterrestrials exist. 

The 2013 paper was discredited by a 2017 paper "Electroencephalographic Recordings During Withdrawal of Life-Sustaining Therapy Until 30 Minutes After Declaration of Death." That 2017 paper studied the brain waves of four humans who died after their hearts stopped. Referring to the 2013 paper, the 2017 paper stated, "We also did not observe any well-defined EEG states following the early cardiac arrest period as previously reported in rats." But in the articles of those trying to portray some neural explanation for near-death experiences, we read no mention of this 2017 paper. Such articles keep citing the 2013 study involving rats, but won't tell us about a more relevant 2017 study involving humans. 

An outrageous 2022 example of fake news was a recent story in the British new source The Independent, a story with the phony headline, "Brain scan reveals patient’s ‘last thoughts’ just before they died in landmark study." Below are some of the reasons the headline and the story are as phony as a three-dollar bill: 

  • The scientific study ("Enhanced Interplay of Neuronal Coherence and Coupling in the Dying Human Brain") made no claim to have revealed the thoughts of the dying 87-year-old patient, nor did it even make any guess about such a thing. 
  • No one is quoted in the article referring to last thoughts.
  • The headline uses the phrase "just before they died," suggesting there were multiple patients involved in the new study; but there was only one patient. 
  • The patient did not actually have his brain scanned as he died. Brain scans are done with MRI machines, and the patient was not being scanned in an MRI machine or any similar machine when he died.  Instead, there was a merely a reading of electrical activity by means of EEG electrodes. 
  • There was nothing "landmark" about the study, as there have been electrode readings of the brain activity of numerous previous patients as they died.  The subtitle of the story makes the untrue claim that there were "first-of-a-kind brain scans," when nothing "first-of-a-kind" was done, and no brain scan was done.  
  • There are very strong reasons for assuming that the patient in question was unconscious in the moments before death, and that he therefore was not thinking about anything just before dying. 

A Frontiers press release is guilty of getting the ball rolling on this fake news story, by suggesting the utterly groundless idea that the EEG readings from a seizure-wracked dying patient in a coma did something to suggest the patient was recalling events in his life.  Here is a quote from the press release:

" 'We measured 900 seconds of brain activity around the time of death and set a specific focus to investigate what happened in the 30 seconds before and after the heart stopped beating,' said Dr Ajmal Zemmar, a neurosurgeon at the University of Louisville, US, who organised the study. 'Just before and after the heart stopped working, we saw changes in a specific band of neural oscillations, so-called gamma oscillations, but also in others such as delta, theta, alpha and beta oscillations.' Brain oscillations (more commonly known as ‘brain waves’) are patterns of rhythmic brain activity normally present in living human brains. The different types of oscillations, including gamma, are involved in high-cognitive functions, such as concentrating, dreaming, meditation, memory retrieval, information processing, and conscious perception, just like those associated with memory flashbacks. 'Through generating oscillations involved in memory retrieval, the brain may be playing a last recall of important life events just before we die, similar to the ones reported in near-death experiences,'  Zemmar speculated. "

Notice the nonsense reasoning here. It's basically this:

(1) People have different types of brain waves, which occur when they do various things like thinking, recalling, meditating (which does not involve recall), and perceiving. 

(2) Some brain waves were measured in a person who died. 

(3) So maybe he was recalling important life events. 

This is nonsensical logic. The study has not provided the slightest reason for thinking that the dying person was remembering past events in his life. To the contrary, we can think of the strongest reason why a person would not be recalling important life events after having a sudden heart attack. The sudden heart attack would produce great pain and great distress, and under such conditions if you were conscious you would be no more likely to be recalling past life events than you would be if someone suddenly stabbed you in the chest. In fact, sudden fatal heart attacks instantly produce unconsciousness which should prevent anyone from engaging in thinking about past events.  

The scientific paper describes the patient's condition before death, and we learn of a state so dire that any speculation about the patient reliving past memories seems supremely absurd. We are told the patient was a 87-year-old who had suffered a fall, and who was in a coma (rating 10 on the Glascow Coma Scale, meaning a moderate coma). Here is how the paper describes the patient's death. 

"An electroencephalography (EEG) was obtained, which showed non-convulsive status epilepticus in the left hemisphere. There were at least 12 identified electrographic seizures, after which a burst suppression pattern spontaneously developed over the left hemisphere (Figure 2A).  Shortly thereafter, electrographic activity over both hemispheres demonstrated a burst suppression pattern, which was followed by development of ventricular tachycardia with apneustic respirations and clinical cardiorespiratory arrest. After discussion with the patient’s family and in consideration of the 'Do-Not-Resiscitate (DNR)' status of the patient, no further treatment was administered and the patient passed away."

Given such a patient state, it is obvious folly to be speculating  that such a patient was reliving past memories just before death. Status epilepticus is a life-threatening seizure of particularly long length. Apneustic respirations are a kind of gasping suggesting death is very near.  Twelve seizures would have produced a "witch's brew" of brain signals showing up on EEG readings, and from such a thunderstorm of brain signals nothing reliable can be inferred about what a patient was thinking or recalling. Since the patient was in a coma and plagued by a dozen seizures that disrupt mental processes such as recollection if it is occurring, it makes no sense at all to speculate that the patient was thinking about or recollecting anything.

Giving us a headline as phony as the headline quoted above from the Independent, the Daily Mail gives us this fake news headline about this patient: "Our lives really DO flash before us: Scientists record the brain activity of an 87-year-old man at the moment he died, revealing a rapid 'memory retrieval' process."  This headline is as phony as a three-dollar bill.  Zero evidence has been provided in the scientific paper of any memory retrieval around the time of death,  and the patient's condition gives the strongest reason for disbelieving that any such thing was occurring. A similar fake news headline occurs on www.bbc.com, showing that once an expert lights a fake news match, the fake news fire will spread even to sources the average person regards as having high journalistic standards. Dozens of news site repeated the groundless claim that neuroscientists had used medical technology to show that someone's life flashes before their eyes when they are dying. 

There is an abundance of reliable evidence that people have extraordinary near-death experiences after their hearts have stopped.  Such experiences often include what are called life-review experiences, in which a person may recall important moments from his life.  Neuroscience has done nothing to explain such near-death experiences, nor has neuroscience provided any evidence that such life reviews occur. We know they occur solely because of eyewitness testimony.  

The paper here casts cold water on the "Enhanced Interplay of Neuronal Coherence and Coupling in the Dying Human Brain" paper discussed above, implying that whatever it observed may have been an artifact of muscle movement, which produces confounding signals in EEG readings. 

Misleading Claims in Attempts to Neurally Explain Out-of-Body Experiences

Misstatements about out-of-body experiences are common in papers and articles written by those trying to naturally explain such experiences. An example is to be found in the paper "The Out-of-Body Experience: Disturbed Self-Processing at the Temporo-Parietal Junction."  The authors make this very erroneous claim: "OBEs have been observed predominantly in patients with epilepsy and migraine." No, out-of-body experiences do not mostly occur in people who have epilepsy or migraines. 

The attempt of the authors to justify such a claim suggests a great shortfall of scholarship on this topic. After making the extremely untrue statement above, they try to justify it by claiming this: "Thus, Lippman (1953) reported two migraine patients with OBEs, and Green (1968) reported that 11% of the OBE subjects that participated in her survey suffered from migraine headaches." Any person who seriously studied out-of-body experiences would have found out that surveys report them occurring in significant fractions of the human population, and would realize the utter folly of trying to justify a claim that out-of-body experiences are caused mainly by migraines or epilepsy by citing a mere two patients having migraines and out-of-body experiences. And anyone writing carefully would have realized the folly of trying to justify a claim that most out-of-body experiences are produced by migraines or epilepsy by citing some person claiming that merely 11% of some group of people having out-of-body experiences had migraines.

Trying to claim that out-of-body experiences are largely caused by migraine headaches makes no sense. In a book about near-death experiences and out-of-body experiences (OBEs), Dr. Peter Fenwick states, "A prominent feature of OBEs is that pain is entirely absent." But since migraine headaches are episodes of intense pain, it makes no sense to claim they are the cause of painless out-of-body experiences.  The source here discusses a variety of surveys taken to try to determine how common out-of-body experiences are.  It gives  numbers which suggest that out-of-body experiences occur to significant fractions of the human population, something like between 10% and 20%.

When materialists attempt to offer natural explanations for out-of-body experiences, what very often goes on is that experiences that are not out-of-body experiences are described as out-of-body experiences. The materialist is very eager to claim as many naturally-explicable experiences as out-of-body experiences. So he will try to use the term "out-of-body experience" to describe very many things, often things that do not have the characteristics of out-of-body experiences. 

In psychiatry and neuoscience, there is a term "autoscopy," A paper states, "Autoscopy is thought to be a rare phenomenon in which a person visualizes or experiences a veritable hallucinatory image of his double."  A paper states, "there is no disembodiment in autoscopy and always disembodiment in OBEs," although the later part of this statement is not correct, because in out-of-body experiences a person may report a kind of different body other than his physical body. A type of misleading statement that sometimes occurs is when materialists describe mere cases of autoscopy (which should not be called out-of-body experiences) as out-of-body experiences. These attempts to use evidence for autoscopy as part of trying to explain out-of-body experiences are misleading and also futile, because of the extreme rarity of reported cases of autoscopy, and the high incidence of cases of out-of-body experience. 

Another example of misleading claims in attempts to naturally explain out-of-body experiences is when a researcher claims to experimentally produce an out-of-body experience. An example is the paper "The Experimental Induction of Out-of-Body Experiences."  The paper describes a fancy high-tech experimental setup in which subjects are given something like virtual reality goggles.  We read this:

"In the first experiment, participants sat on a chair, wearing a pair of head-mounted displays that were connected to two video cameras placed side by side 2 m behind the participant’s back (Fig. 1A). The images from the left video camera were presented on the left eye display and the images from the right camera on the right display. Thus, the person would see his or her back with the perspective of a person sitting behind him or her with stereoscopic vision."

The author gives no justification for his claim that this very fancy high-tech setup produced any out-of-body experience. The paper gives no account by anyone describing an out-of-body experience. What is going on here is some high-tech setup designed to create perceptual confusion in subjects. Since the high-tech setup bears no resemblance to anything people would experience in normal life, the experiment in worthless in explaining out-of-body experiences, which do not occur when people are wearing virtual reality goggles. The author should not have given his paper his paper the misleading title "The Experimental Induction of Out-of-Body Experiences." An honest title would have been something like "Induction of Perceptual Confusion by Special Goggles." 

Another misleading and irrelevant paper claiming to have experimentally produced an out-of-body experience is the paper "Experimental Elicitation of an Out of Body Experience and Concomitant Cross‐Hemispheric Electroencephalographic Coherence." This ethically questionable paper involved zapping the brain of a single subject with some special hat containing "64 solenoids (see Figure 1) obtained from Radio Shack," until a headache was produced in the subject. Experimenting with crudely constructed brain-zapping devices not approved by the FDA was morally dubious. The paper gives no quotation from the subject describing an out-of-body experience. We read this:

"The experience culminated with the subject feeling his head was floating above the spot where his body was sitting. He could not distinguish between his limbs, his torso, or the surrounding space and objects in the room. During this intense experience, he considered asking the experimenter to terminate the procedure. Following the experience there was noticeable fatigue and a headache developed."

This is a description of severe disorientation, confusion and pain, not matching what is reported in out-of-body experiences, in which people report painless clear perception of their body from a spot outside of their body. Since the paper does not include a first-hand account of the user's mental experiences, but merely a second-hand account of someone's mental experiences (one that may be biased by the experimenters' desire to report an out-of-body experience), the paper fails to provide any good evidence that an out-of-body experience occurred. Since the paper involves some high-tech brain-zapping setup unlike anything existing when ordinary people have out-of-body experiences, such a paper is worthless in explaining out-of-body experiences. 

A similar paper (authored by one of the authors of a misleading paper mentioned above) is entitled "Stimulating illusory out-of-body experiences." The paper has some quotes by a subject in whom the authors had brain-zapped with electricity, by inserting electrodes in her brain. The authors have attempted to portray this as evidence of an artificially induced out-of-body experience. But the only sentence that the paper quotes from the subject is one that does not indicate a full out-of-body experience. That sentence is this: "I see myself lying in bed, from above, but I only see my legs and lower
trunk." That sounds like some weird electricity-induced perception anomaly that is not properly described as an out-of-body experience. During an out-of-body experience a person will typically report leaving his body and seeing his entire body (not just the legs and lower trunk) from outside of the body. Eager to report some experimental induction of an out-of-body experience, our authors seem to have taken some account that does not match those of out-of-body experiences, and called that an out-of-body experience. The authors make this claim: "Two further stimulations induced the same sensation, which included an instantaneous feeling of 'lightness' and 'floating' 'about two metres above the bed, close to the ceiling." Since this is not an actual full-sentence quote from the subject, it has no value as evidence. A second-hand account of a person's experience during brain zapping (by some other person who did not have that experience) is worthless as evidence. What would we have read from a transcript of what the subject said? We have no idea. 

With the misleading stories and papers I have cited, neuroscientists and materialists are trying to make it look a little bit like they have some neural or natural explanation for near-death experiences or out-of-body experiences. They have no such thing. The phenomena of near-death experiences and out-of-body experiences are utterly inexplicable under the dogmas and assumptions of most neuroscientists and materialists, such as the dogma that the brain produces the mind or the dogma that mind states are mere brain states. All the things we see occurring in near-death experiences and out-of-body experiences are things that should not be occurring if such dogmas and assumptions are correct. Near-death experiences and out-of-body experiences are evidence that such dogmas and assumptions are incorrect. It would be hard to imagine a more resounding refutation of the dogma that your brain makes your mind than what is reported in out-of-body experiences: people observing their bodies from outside of their bodies. 

Postscript: Another study pretending to offer some insight about out-of-body experiences is the 2023 study "Causal evidence for the processing of bodily self in the anterior precuneus" study I discuss at great length in my post here. Making several untrue statements about its own witness reports, the study tries to produce out-of-body experiences by brain zapping, but fails. None of its reports is an actual report of an out-of-body experience. What has gone on is that doctors interviewing brain-zapped subjects have used many a "leading question" to try to pull out of the patients something sounding a little like an out-of-body experience. In no case did they get what they were trying very hard to elicit.  The closest they get is someone saying that a brain zapping produced in him a feeling that was "just kinda like got like thrown up on the clouds," a statement so weakly worded and poetical-sounding that it does not qualify as being a statement of an out-of-body experience.  The whole idea of  electrically zapping people's brains to try to explain out-of-body experiences is absurd, because the people reporting such experiences did not have their brains zapped when they had such experiences. 

Another example of misleading statements is found in the article "Meditation-Induced Near-Death Experiences: a 3-Year Longitudinal Study." The title is misleading, because the mystical experiences discussed were not experiences occurring during any bodily danger. An experience that does not occur when someone is near death should not be called a near-death experience. We have here a study that is an example of researchers planting suggestions in the minds of subjects. First people engaging in deep meditation were recruited to join some group, with the expectation being raised that they would report something like a near-death experience. The people were told to contact one of the researchers as soon as they had something like a near-death experience, and upon making such a contact the people were then asked leading questions trying to elicit from them something sounding like a near-death experience.  A study like this has little value as evidence unless it gives an interview transcript for each of the person's experience, or an account written by each of them. But we are given no such things. We are told that none of the participants reported two of the hallmarks of a near-death experience: speeded-up thinking and coming to some point of no return. 

See my post here for a discussion of an extremely misleading article in The Guardian about near-death experiences.  See the end of my post here for a discussion of why the 2017 study "Characterization of end-of-life electroencephalographic surges in critically ill patients" fails to provide any evidence of brain activity surges after a heart has stopped. The study was one that only had EEG data on brain wave activity, not any corresponding data on heart rate activity. The same post gives an example of misleading language by a neuroscientist describing a DMT drug trip, and unsuccessfully trying to make it sound rather like a near-death experience. 

Sunday, October 23, 2022

Poorly Designed Brain Scan Experiments Needlessly Put the Needy at Risk

Neuroscientists commonly do brain scan studies that use small study group sizes of fewer than 20 subjects per study group. Not long ago a press release from the University of Minnesota Twin Cities announced results which indicate that such small-sample correlation-seeking brain imaging experiments are utterly unreliable.  The headline of the press release is "Brain studies show thousands of participants are needed for accurate results."

In the announcement we read this:

"Scientists rely on brain-wide association studies to measure brain structure and function—using MRI brain scans—and link them to complex characteristics such as personality, behavior, cognition, neurological conditions and mental illness. New research published March 16, 2022 in Nature from the University of Minnesota and Washington University School of Medicine in St. Louis...shows that most published brain-wide association studies are performed with too few participants to yield reliable findings."

The abstract of the paper in the science journal Nature can be read here. The paper is entitled, "Reproducible brain-wide association studies require thousands of individuals." 

The press release tells us this:

"The study used publicly available data sets—involving a total of nearly 50,000 participants—to analyze a range of sample sizes and found:

  • Brain-wide association studies need thousands of individuals to achieve higher reproducibility. Typical brain-wide association studies enroll just a few dozen people.
  • So-called 'underpowered' studies are susceptible to uncovering strong but misleading associations by chance while missing real but weaker associations. 
  • Routinely underpowered brain-wide association studies result in a surplus of strong yet irreproducible findings."
The paper was released in March, 2022, but there is so far no sign that universities and neuroscientists are paying much attention to its very important findings. Universities continue to release shoddy press releases making dubious claims about the results of low-quality neuroscience experiments that use MRI scanning, poorly designed experiments that use fewer than 15 subjects per study group. A recent example is a Carnegie Mellon University press release trying to insinuate that neuroscientists have found something about "how abstract concepts are represented in the brain." No such thing has happened, because the study was yet another brain scan study using way too small study group sizes. 

A look at the paper reveals that the study group sizes were only 10 subjects per study group.  Failing to follow any blinding protocol, failing to do any sample size calculation, and failing to report any effect size, the study offers no robust evidence for anything. For the sake of this poorly designed study, twenty subjects (10 in each study group) had their brains scanned for 1 hour with a 3T scanner that may have health risks that I discuss below. Besides wasting federal funds, such studies may actually be putting subjects at risk by exposing them to long unnecessary brain scans that may have negative health effects, particularly decades down the road. 

Another poorly designed brain scan study is a study announced with the press release below. The red circling shows one of countless examples I can give of how university press releases shamelessly hype, distort and exaggerate (a far-fetched speculation that brains might possibly use quantum computation is announced as simply a finding that brains do use quantum computation):

hype in university press release

The study in question needlessly subjected 40 subjects to brain scanning with a 3T scanner (possibly dangerous for reasons discussed below). It seems nothing worthwhile was accomplished in the way of good experimental science because of the poor design of the study. It was not a pre-registered study; the study did not follow any blinding protocol; and there was no sample size calculation to determine whether the study group sizes used were adequate.  Failing to meet any of the main hallmarks of a good experimental study, the study fails to report any effect size, fails to report any  statistical significance, and mentions study group sizes way too small, including one group of only seven subjects and another group of only five subjects. The study refers to "1000 scans," causing me to worry about how much radiation these subjects were needlessly subjected to for a study so poorly designed.  

An example of a poorly designed study which may have needlessly put many at risk was the study "Human cerebellum and corticocerebellar connections involved in emotional memory enhancement." Unlike the vast majority of neuroscience experiments, this study used a large sample size, and consisted of 1418 people who were brain-scanned. Unfortunately, the results are pretty worthless, because of a failure of the scientists to follow best practices. The paper makes no mention of a blinding protocol, an essential for a paper like this to be taken seriously.  The study was not a pre-registered study. There was no declaration before gathering of a specific hypothesis to be tested, and a protocol of how data would be gathered and analyzed.  So the scientists were free to keep slicing and dicing the data until they squeezed out a little "statistical significance" from some nook or cranny. The authors failed to report any specific percent signal change produced during memory activity. They fail to report results of any impressive statistical significance. Their best result is a mere "p < 0.05," which is scarcely worth even reporting. Many (such as the seventy experts who authored this paper) think that the criteria for statistical significance should be tightened, so that nothing should be reported as being statistically significant unless it has p < 0.005. 

The subjects undergoing a half hour of brain scanning were paid a mere 25 Swiss Francs per hour that they were scanned, a trifling sum to be paid for being exposed to a significant risk.  The subjects were brain scanned for 30 minutes (a medical MRI scan takes maybe 15  minutes). The more dangerous type of 3T scanner was used, a scanner type that has the possible health risks described below. 

We can imagine the people who showed up for such a poor payment, amounting effectively to maybe $5 or $10 an hour (when you take into account transportation time, the time needed to exclude subjects facing higher risks by scanning, the training time required before scanning, and the time waiting for an MRI scanner to become ready). In general only the financially neediest people would have been induced by such a paltry payment.  Similarly, the poorly designed GABA study described in this post subjected children to unnecessary brain scans by a powerful 3T scanner, and paid them a mere 25 pounds (nowadays worth about 28 dollars).  What parent would allow such a thing for so a small a sum? Perhaps only one so needy as to have trouble feeding his child adequately. 

It is a dogma among neuroscientists that MRI scans are safe. But we should remember that neuroscientists are very dogmatic creatures who often repeat claims that are dubious and unproven (as you can tell by reading the posts on this blog).  Do we really know that MRI scans are free of any risk?

One danger of MRI scans is well-known: the risk of the very strong magnets used by such machines causing some metal object to be hurled at a high speed, causing injury or death.  In 2001 a six-year-old boy was killed in the US during an MRI scan, when the machine turned an oxygen canister into a flying projectile.  There is always a risk of lingering psychological trauma when certain people are put in some noisy high-tech machine and told they must be silent and not move for a long time such as an hour. There is also the risk that the more powerful MRI scans may raise the risk of cancer in the person getting the scan. 

In the wikipedia.org article for Functional Magnetic Resonance Imaging, we read the troubling passage below:

"Genotoxic (i.e., potentially carcinogenic) effects of MRI scanning have been demonstrated in vivo and in vitro, leading a recent review to recommend 'a need for further studies and prudent use in order to avoid unnecessary examinations, according to the precautionary principle'. In a comparison of genotoxic effects of MRI compared with those of CT scans, Knuuti et al. reported that even though the DNA damage detected after MRI was at a level comparable to that produced by scans using ionizing radiation (low-dose coronary CT angiography, nuclear imaging, and X-ray angiography), differences in the mechanism by which this damage takes place suggests that the cancer risk of MRI, if any, is unknown."

The 2009 study here ("Genotoxic effects of 3 T 
magnetic resonance imaging in cultured human lymphocytes")
cautions about the use of a high-intensity
("3T and above") MRI, and states that 
"potential health risks are implied in the MRI and especially
HF MRI environment due to high-static
magnetic fields, fast gradient magnetic fields, and strong 
radiofrequency electromagnetic fields," also noting that 
"these results suggest that exposure to 3 T MRI induces
 genotoxic effects in human  lymphocytes," referring to effects
 that may cause cancer. 

paper tells us the following about the newer twice-as-powerful
3T MRI machines that have been replacing the older 1.5T MRI
machines, suggesting their magnetic fields are much stronger than
the strength needed to lift a car:

"The main magnetic field of a 3T system is 60,000 times
 the earth's magnet field. The strength of electromagnets
 used to pick up cars in junk yards is about the field strength 
of MRI systems with field strengths from 1.5-2.0T.
 It is strong enough to pull fork-lift tires off of machinery,
 pull heavy-duty floor buffers and mop buckets into
 the bore of the magnet, pull stretchers across the room
 and turn oxygen bottles into flying projectiles reaching
 speeds in excess of 40 miles per hour."   

A 2021 paper on MRI safety makes the not-very-reassuring claim that "no conclusive proof of harmful biological effects has been found to be caused by the static magnetic field up to 7T."  This sounds like what cigarette manufacturers told us for years between 1950 and 1970, that there was no conclusive proof that cigarettes cause cancer (now such conclusive proof exists).  When there is no evidence at all that something is harmful, a person will say something like "there is not a shred of evidence that it is harmful." When there exists some evidence suggesting a danger, a person may claim that there is "no conclusive proof" of harm. 

brain scan risks
Needlessly putting the needy at risk, usually for the sake of junk science

Will some of these subjects who participated in the usual poorly-designed brain scan studies end up with cancer decades from now because they were subjected to 30 to 60 minutes of unneeded 3T MRI scanning which "induces genotoxic effects" according to the previously cited paper?  We'll probably never know, because neuroscientists don't seem to keep track of the long-term health results of the people they have brain-scanned in their experiments. It's kind of a policy of "scan 'em and forget 'em." Our neuroscientists are fond of saying there is "no proof" that MRI imaging can be harmful, but that's because they are not doing the long-term patient health followup tracking to determine whether MRI imaging produces a greater risk of cancer over 30 years or 40 years. 

Don't put me down as being anti-MRI (I've had an MRI myself, after being advised by a doctor to do so).  In countless medical treatment cases, the benefits of an MRI scan are greater than the small risks. But people should not be put at risk by getting unnecessary brain scans solely for the sake of poorly designed studies that fail to prove anything because they followed Questionable Research Practices. 

I am not at all suggesting anyone should avoid an MRI scan when a doctor recommends such a thing as medically advisable. But it is rather clear that in their zeal to load up their resumes with more and more brain scanning studies, our neuroscientists are rounding up too many paid subjects for unnecessary and potentially harmful brain scans.  What is really tragic is that such a large fraction of experimental brain scan studies follow Questionable Research Practices so badly that they qualify as "junk science studies" failing to provide any robust evidence for anything important.  It seems that very often human research subjects may be needlessly put at increased risk of cancer and other health dangers by being brain-scanned in scanners such as 3T MRIs, merely so that neuroscientists can round up more subjects for badly designed studies that do nothing to advance science because they fall very short of meeting the standards of good experimental science.   

When neuroscientists say brain scans are safe, they are referring to how much health trouble is now observed in people whose brains are scanned. No one has done some 25-year longitudinal study on the topic of whether people whose brains were scanned with 3T MRIs have a higher chance of  cancer 25 or 30 years in the future.  3T MRIs were only approved by the FDA in the year 2000.

A scientific paper states this, referring to 3T MRIs:

"An insufficient number of validated studies have been carried out to demonstrate the safety of high strength static magnetic field exposure (Shellock, 2009). While MRI has been used for many years in the clinic, at higher Tesla levels (over 3 Tesla) the technology is relatively novel. Even less information about potential negative health effects exists for specific populations such as pregnant women and children." 

The 2022 paper here discusses a large range of health concerns involving MRI scanners, such as these:

"The strong static magnetic field (B0) of MRI scanners can attract and accelerate ferromagnetic objects toward the center of the machine and turn them into dangerous projectiles...The radiofrequency (RF) field that is created by RF-coils can potentially cause tissue heating, especially in the presence of implants....The Time-varying fast-switching gradient magnetic field function is a spatial encoding of the MRI signal and can stimulate muscles or peripheral nerves and induce implant heating. They also produce noise in the MRI scanner space, which can reach levels of 100 dB or more and damage the hearing system."

If I were an ethical advisor asked to approve proposals for brain experiments, I would have the following rules:
  • I would never approve the use of human brain scanning for any experimental study that used fewer than 25 subjects for any of its study groups, because such studies are way too likely to produce false alarms.  I would never approve the use of any brain scanning experiment that did not include a sample size calculation to determine an adequate sample size that was used as a minimum for each study group. 
  • I would never approve the use of human brain scanning for any experimental study that had not published publicly a detailed research plan, including a precise hypothesis to be tested, along with a very exact and detailed description of how data would be gathered and analyzed. We should not be putting people at risk for studies that do not follow best practices. 
  • I would never approve the use of human brain scanning for any experimental study that had not published publicly a detailed blinding protocol to be followed, discussing exactly how blinding techniques would be used to reduce the risk of experimenter bias in which the experimenter "sees what he wants to see." We should not be putting people at risk for studies that do not follow best practices. 
  • I would insist that any consent form signed by a subject to be brain scanned would include a detailed discussion of the reasons why brain scanning might be potentially hazardous, with negative effects appearing far in the future, along with a fair discussion of the scientific literature suggesting such hazards. Currently a large fraction of such consent forms fail to frankly discuss such risk. 
  •  I would never approve the use of any brain scanning on children in an experiment that did not absolutely require the participation of children. 

I strongly advise all parents never to let their children participate in any brain scanning experimental study unless a doctor has told them that the brain scan is medically advisable solely for the health of the child.  I advise adults not to participate in any brain scanning experimental study unless they have read something that gives them warrant for believing that the experimenters are following best experimental practices, and that there will be not be a very high chance that the adults will be undergoing unnecessary health risks for the sake of some "bad practices" poorly designed "fishing expedition" experiment that does not advance human understanding.  If a neuroscientist looking for research subjects tells you that brain scans are perfectly safe, remember that many neuroscientists often dogmatically make claims that are unproven or doubtful, and often pretend to know things they do not actually know (see this site for very many examples). 

I also strongly advise anyone who participated in any brain scanning experiment to permanently keep very careful records of their participation, to find out and write down the name of the scientific paper corresponding to the study, to write down and keep the names of any scientists or helpers they were involved with, to permanently keep a copy of any forms they signed, and to keep a careful log of any health problems they have. Such information may be useful should such a person decide to file a lawsuit. 

When we examine the history of MRI scans, we see a history of overconfidence, and authorities dogmatically asserting that "MRI scans are perfectly safe," when they did not actually know whether they were perfectly safe.  Not many years ago there arose the great "contrast agent" scandal.  Scientists began to learn that what are called "contrast agent" MRI scans (given to 30 million people annually) may not be so safe. In such "contrast agent" scans, a subject is given an injection that increases the visual contrast of the MRI scan.  For a long time, the main substance in such an injection was gadolinium.  A mainstream cancer web site states, "Tissue and autopsy reports have also confirmed that gadolinium can accumulate in the brain and other organs." The results can be a health disaster, as described here. A 2019 Science Daily story says, "New contrast agent could make MRIs safer," letting us know that many of them previously were not so safe. On the same Science Daily web site, we read a 2017 news story with the title "MRI contrast agents accumulate in the brain."  A 2020 paper ("Side Effect of Gadolinium MRI Contrast Agents") says this:

"Until recently, it was believed that gadolinium is effectively cleared within 24 hours after intravenous injection, and that it does not have any harmful effects on the human body. However, recent studies on animals and analyses of clinical data have indicated that gadolinium is retained in the body for many years post-administration, and may cause various diseases."

Neuroscientists extensively used such contrast agents (as described here), very often putting human subjects at risk for the sake of junk poorly designed studies falling far short of the best experimental practices. All the while,  many of our experts were making the untrue claim that "MRI scans are perfectly safe," a statement which was not clearly  true for the large fraction of MRI studies that used gadolinium contrast agents. You can do a Google search for "gadolinium deposition" to learn more about this issue. 

A while ago there was published a scientific paper entitled "The effects of repeated MRI on chromosomal damage." Despite making in its abstract the claim that "MRI is a safe imaging technique," the paper finds results that are worrying. We are told, "The total number of damaged cells increased by 3.2% (95% CI 1.5–4.8%) per MRI (Fig. 2d–h) (p< 0.001); this increase being higher during the first ten MRI sessions than during the last ten ones."

Is there any protocol in place to prevent subjects from being used more than once in a neuroscience brain scan study? Apparently not, because Table 1 of the paper above mentions some subjects of the Human Brain Project being given more than 25 MRI brain scans, none of them medically necessary.  The blase attitude of experimental neuroscientists towards health risks to their brain scan subjects is very appalling.  Not only do they fail to track the long-term health of the subjects scanned ("scan 'em and forget 'em,") but also seem to pay no attention to how many times their subjects have been scanned, ignoring cumulative risk. 

Most appallingly, our neuroscientists seem to fail to honestly notify their human subjects of the risks they are undergoing before engaging in possibly dangerous 3T brain scans so that the financially needy subjects can earn trifling sums. After doing a Google search for "brain scan experiment consent form," I find several actual consent forms and "model" consent forms containing dishonest language, such as the claim that there are "no known significant risks or side effect associated with MRI scans." That is not honest language, given the statements I have discussed above. One "template" for brain scan studies recommended by a university has these ridiculously inconsistent statements (the first untrue statement being contradicted by the rest of the statements):

"There are no known significant risks or side effects associated with MRI scans...There is a risk if metal objects are near the MRI because they can be drawn into the MRI scanner
and that could hurt someone in or near the machine...There may be risks associated with this study that we do not know about. In spite of all the care and precautions taken by the investigators, you might develop medical complications from participating in this study."

One horrid form by a major university asks participants to be scanned for an hour in an MRI machine as a "dry run" to test the machine or its settings. The form states this:

"The procedure may involve unexpected risks that are impossible to predict. These unforeseen risks may affect you during your participation in the procedure and/or at some point in the future...You will not be helped by participating in this procedure....You will not be paid for participating in this study....If you are hurt as a result of participating in the 'dry run exam', we have no plans to pay you for lost wages, disability, or discomfort."

In general, the MRI consent forms I looked at totally failed to warn participants of the risk of cell damage and the increased chance of getting cancer as a result of a 1 hour 3T brain scan, something everyone should be warned of. As mentioned above, the 2022 paper "The effects of repeated brain MRI on chromosomal damage" found that "The total number of damaged cells increased by 3.2% (95% CI 1.5–4.8%) per MRI." The paper was referring to "DNA breaks" that have a possibility of increasing cancer risk.  The paper referred to 90-minute 3T scans much longer than the average diagnostic MRI brain scan, which takes maybe 15 minutes and presumably damages much less than 1% of cells.

A paper entitled "A massive 7T fMRI dataset to bridge
3 cognitive neuroscience and artificial intelligence" discusses some data collection in which eight subjects were brain scanned 30 to 40 times with 7T scanners twice as powerful as the 3T scanners mentioned above, with each scan being about an hour long. The paper states this: 

"The total number of 7T fMRI scan sessions were 43, 43, 35, 33, 43, 35, 43, and 33 for subj01–subj08, respectively. The average number of hours of resting-state fMRI conducted for each subject was 2.0 hours, and the average number of hours of task-based fMRI conducted for each subject was 38.5 hours."

This was in addition to other 3T scans the subjects were given.  The paper makes no mention of any consideration of health risks to these people, who received only $30 per hour for the medically unnecessary scans. A 7T scanner would presumably have more than twice the risks of the 3T scanners discussed above.  

Postscript: The latest example of needless risk to subjects is a study with a preprint entitled "Semantic reconstruction of continuous language from non-invasive brain recordings." The study failed to show any good evidence for anything important, as it used a way too-small study group size of only seven subjects (15 subjects per study group is the minimum for a moderately impressive result). Following Questionable Research Practices, the scientists report no sample size calculation, no blinding protocol, no pre-registration, no control group, and no effect size. The only "statistical significance" reported is what smells like "p-hacking" kind of results of the bare minimum for publication (merely p < .05). For these basically worthless results, seven subjects endured something like 16 hours of brain scanning with a 3T scanner, which is more than 30 times longer than they would have had for a diagnostic MRI.  Senselessly, this study has been reported by our ever-credulous science press as some case of reading thoughts by brain scanning. It is no evidence of any such thing. 

A 2005 article in Nature discusses second brains scans required in NIH-funded experiments, apparently to help clarify which subjects have brain anomalies that need to be reported to physicians. We read this about some workshop of "about 50 scientists, physicians, lawyers and ethicists": 

"The NIH goes one step further by requiring its on-campus investigators to perform a clinical scan of every research subject, in addition to any research scans. But workshop participants agreed that this was not a good idea because it can expose people to unnecessary risks from extra procedures."

So the scientists seemed to agree that having two brain scans was  exposing subjects to "unnecessary risks." So why are we having so many poorly designed neuroscience experiments in which so many subjects are needlessly subjected to such "unnecessary risks"? And why are some subjects being subjected to more than ten brain scans in such poorly designed experiments?